IL36RN

Gene Symbol IL36RN
Entrez Gene 26525
Alt Symbol FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14
Species Human
Gene Type protein-coding
Description interleukin 36 receptor antagonist
Other Description IL-1 related protein 3|IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta)|IL-1ra homolog 1|IL1F5 (Canonical product IL-1F5a)|interleukin 1 family, member 5 (delta)|interleukin-1 HY1|interleukin-1 receptor antagonist homolog 1|interleukin-1-like protein 1|interleukin-36 receptor antagonist protein
Swissprots Q7RTZ6 Q56AT9 A8K2I4 Q9UBH0
Accessions AAF76981 AAX59031 AAY14990 CAB67704 CAC27298 CAD29877 EAW73617 EAW73618 Q9UBH0 AF186094 AAF02757 AF201830 AAF25210 AF230377 AAF91274 AJ242737 CAB59822 AJ242738 CAB59823 AK002125 AK290249 BAF82938 AY359117 AAQ89475 BC000945 BC024747 AAH24747 DQ890702 ABM81628 DQ893886 ABM84812 NM_012275 NP_036407 NM_173170 NP_775262
Function Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.
Subcellular Location Secreted.
Tissue Specificity Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.

IL-1F5 (D-11) - sc-398515 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-1F5 (D-11): sc-398515. Western blot analysis of IL-1F5 expression in non-transfected 293T: sc-117752 (A), human IL-1F5 transfected 293T: sc-113962 (B), HL-60 (C) and SK-N-MC (D) whole cell lysates.

IL-1F5 (G-15) - sc-51298 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-1F5 (G-15): sc-51298. Western blot analysis of human recombinant IL-1F5.

IL-1F5 (H-85) - sc-292210 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-IL36RN antibody - ab106603 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL36RN antibody (ab106603) at 1 µg/ml + Transfected 293T cell lysate at 10 µg

Anti-IL36RN antibody [MM0384-2J30] - ab90931 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0384-2J30

Anti-IL36RN antibody - N-terminal - ab170671 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labeling IL36RN with ab170671 at 1/10 dilution, followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-IL36RN / IL1F5 Antibody (aa76-104, AP) - LS-C236544 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36RN / IL1F5 Antibody (aa76-104, APC) - LS-C236548 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36RN / IL1F5 Antibody (aa76-104, PE) - LS-C236551 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36RN / IL1F5 Antibody (aa76-104, Biotin) - LS-C236549 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36RN / IL1F5 Antibody (aa76-104, FITC) - LS-C236550 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36RN / IL1F5 Antibody (aa76-104, Azide-free, HRP) - LS-C249260 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36RN / IL1F5 Antibody - LS-C154077 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Bovine IL-1F5 Antibody - Western Blot. Western blot of Protein-A Purified anti-bovine IL-1F5 antibody shows detection of recombinant bovine IL-1F5 at 17.1 kD (arrowhead) raised in yeast. The identity of the band at 36 kD is not known. The protein was purified and resolved by SDS-PAGE, then transferred to PVDF membrane. Membrane was blocked with 3% BSA (BSA-30, diluted 1:10), and probed with 1 ug/mL primary antibody overnight at 4C. After washing, membrane was probed with IRDye800 Conjugated Goat Anti-Rabbit IgG ( for 45 min at room temperature.

Anti-IL36RN / IL1F5 Antibody (C-Terminus) - LS-C116625 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IL1F5 antibody LS-C116625 Western blot of Transfected 293T cell lysate.

Anti-IL36RN / IL1F5 Antibody (C-Terminus) - LS-C135346 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IL1F5 antibody LS-C135346 Western blot of Rat Brain lysate.

Anti-IL36RN / IL1F5 Antibody (aa75-104) - LS-C329673 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36RN / IL1F5 Antibody (aa12-151, Biotin) - LS-C297491 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL36RN / IL1F5 Antibody (aa12-151, FITC) - LS-C305528 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL36RN / IL1F5 Antibody (aa1-156) - LS-C314543 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL36RN / IL1F5.

Anti-IL36RN / IL1F5 Antibody (aa12-151) - LS-C314544 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL36RN / IL1F5.

Anti-IL36RN / IL1F5 Antibody (aa12-151) - LS-C294787 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL1F5.

Anti-IL36RN / IL1F5 Antibody (aa76-104) - LS-C165186 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
IL1F5 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skin tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-IL36RN / IL1F5 Antibody (C-Terminus) IHC-plus™ - LS-B10137 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IL36RN / IL1F5 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10137 concentration 10 ug/ml.

IL-36Ra/IL-1F5 Antibody [Unconjugated] - AF1275 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

IL1F5 Antibody - NBP1-83894 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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