IL36RN

Gene Symbol	IL36RN
Entrez Gene	26525
Alt Symbol	FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14
Species	Human
Gene Type	protein-coding
Description	interleukin 36 receptor antagonist
Other Description	IL-1 related protein 3|IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta)|IL-1ra homolog 1|IL1F5 (Canonical product IL-1F5a)|interleukin 1 family, member 5 (delta)|interleukin-1 HY1|interleukin-1 receptor antagonist homolog 1|interleukin-1-like protein 1|interleukin-36 receptor antagonist protein
Swissprots	Q7RTZ6 Q56AT9 A8K2I4 Q9UBH0
Accessions	AAF76981 AAX59031 AAY14990 CAB67704 CAC27298 CAD29877 EAW73617 EAW73618 Q9UBH0 AF186094 AAF02757 AF201830 AAF25210 AF230377 AAF91274 AJ242737 CAB59822 AJ242738 CAB59823 AK002125 AK290249 BAF82938 AY359117 AAQ89475 BC000945 BC024747 AAH24747 DQ890702 ABM81628 DQ893886 ABM84812 NM_012275 NP_036407 NM_173170 NP_775262
Function	Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.
Subcellular Location	Secreted.
Tissue Specificity	Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL1F5 gene - orb90728 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-IL1F5-cDNA-Clone - DC05443 from Abgent, a WuXi AppTec company Prices $209.25 Sizes 10 µg Species Human Accession BC024747

Human IL1F5 ORF Clone(NM_012275.2) - CDCL167096 from Creative Biomart Species Human Accession NM_012275.2

Human IL1F5 ORF clone(NM_012275.2) - CDCL184811 from Creative Biomart Species Human Accession NM_012275.2

Human IL36RN cDNA clone(NM_173170.1) - CDFG010634 from Creative Biomart Species Human Accession NM_173170.1

Human IL36RN cDNA clone(NM_012275.2) - CDFH009200 from Creative Biomart Species Human Accession NM_012275.2

Human Il36rn ORF clone(NM_173170.1) - CDCH387045 from Creative Biomart Species Human Accession NM_173170.1

Human IL36RN ORF Clone(NM_012275.2) - CDCR295744 from Creative Biomart Species Human Accession NM_012275.2

Human IL36RN ORF Clone(NM_012275.2) - CDCR295745 from Creative Biomart Species Human Accession NM_012275.2

Human IL36RN ORF Clone(NM_012275.2) - CDCR295746 from Creative Biomart Species Human Accession NM_012275.2

Human IL36RN ORF Clone(NM_173170.1) - CDCR321738 from Creative Biomart Species Human Accession NM_173170.1

Human IL36RN ORF Clone(NM_173170.1) - CDCR321739 from Creative Biomart Species Human Accession NM_173170.1

Human IL36RN ORF Clone(NM_173170.1) - CDCR321740 from Creative Biomart Species Human Accession NM_173170.1

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10125-M from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10125-NH from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10125-M-F from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10125-UT from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10125-CY from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10125-CH from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10125-NF from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10125-CF from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10125-NY from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10125-NM from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10125-ACG from Sino Biological Species Human

Human IL-1F5 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10125-CM from Sino Biological Species Human

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