IL36RN

Gene Symbol	IL36RN
Entrez Gene	26525
Alt Symbol	FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14
Species	Human
Gene Type	protein-coding
Description	interleukin 36 receptor antagonist
Other Description	IL-1 related protein 3|IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta)|IL-1ra homolog 1|IL1F5 (Canonical product IL-1F5a)|interleukin 1 family, member 5 (delta)|interleukin-1 HY1|interleukin-1 receptor antagonist homolog 1|interleukin-1-like protein 1|interleukin-36 receptor antagonist protein
Swissprots	Q7RTZ6 Q56AT9 A8K2I4 Q9UBH0
Accessions	AAF76981 AAX59031 AAY14990 CAB67704 CAC27298 CAD29877 EAW73617 EAW73618 Q9UBH0 AF186094 AAF02757 AF201830 AAF25210 AF230377 AAF91274 AJ242737 CAB59822 AJ242738 CAB59823 AK002125 AK290249 BAF82938 AY359117 AAQ89475 BC000945 BC024747 AAH24747 DQ890702 ABM81628 DQ893886 ABM84812 NM_012275 NP_036407 NM_173170 NP_775262
Function	Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.
Subcellular Location	Secreted.
Tissue Specificity	Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL36RN / IL1F5 ELISA Kit (Sandwich ELISA) - LS-F5630 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 15.63-1000 pg/ml

Human IL36RN / Interleukin-36 Receptor Antagonist Protein ELISA Kit - RAB0685 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human IL-36Ra/IL-1F5 DuoSet ELISA - DY1275-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 93.80 - 6,000 pg/mL

Interleukin 1 Delta (FIL1d), Human, ELISA Kit - SEA566Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 5.7pg/mL Range 15.6-1,000pg/mL

Interleukin 37 (IL-37), Human, ELISA Kit - CSB-E16185h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Interleukin-36 alpha (IL1F6), Human, ELISA Kit - CSB-EL011617HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Interleukin-36 beta (IL1F8), Human, ELISA Kit - CSB-EL011619HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Interleukin-36 receptor antagonist protein (IL1F5), Human, ELISA Kit - CSB-EL011616HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 1.95 pg/ml Range 7.8 pg/ml-500 pg/ml

Interleukin 1 Delta, FIL1d, Mouse, ELISA Kit - E-EL-M0718 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Interleukin 1Delta, FIL1d, Rat, ELISA Kit - E-EL-R0550 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Anserine FIL1d ELISA Kit - AF0096 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Interleukin 1 Delta, ELISA Kit - MBS030724 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Delta, ELISA Kit - MBS045834 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Delta, ELISA Kit - MBS035858 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Delta, ELISA Kit - MBS029971 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Delta, ELISA Kit - MBS013858 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Delta, ELISA Kit - MBS735015 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Delta, ELISA Kit - MBS722985 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Delta, ELISA Kit - MBS733481 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Delta, ELISA Kit - MBS739371 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Interleukin 1 Delta, ELISA Kit - MBS737073 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/mL.

Interleukin 1 Delta, ELISA Kit - MBS736054 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Interleukin 1 Delta, ELISA Kit - MBS739383 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Interleukin 1 Delta, ELISA Kit - MBS041273 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Delta, ELISA Kit - MBS082493 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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