| Gene Symbol |
IL36RN
|
| Entrez Gene |
26525
|
| Alt Symbol |
FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 36 receptor antagonist
|
| Other Description |
IL-1 related protein 3|IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta)|IL-1ra homolog 1|IL1F5 (Canonical product IL-1F5a)|interleukin 1 family, member 5 (delta)|interleukin-1 HY1|interleukin-1 receptor antagonist homolog 1|interleukin-1-like protein 1|interleukin-36 receptor antagonist protein
|
| Swissprots |
Q7RTZ6 Q56AT9 A8K2I4 Q9UBH0
|
| Accessions |
AAF76981 AAX59031 AAY14990 CAB67704 CAC27298 CAD29877 EAW73617 EAW73618 Q9UBH0 AF186094 AAF02757 AF201830 AAF25210 AF230377 AAF91274 AJ242737 CAB59822 AJ242738 CAB59823 AK002125 AK290249 BAF82938 AY359117 AAQ89475 BC000945 BC024747 AAH24747 DQ890702 ABM81628 DQ893886 ABM84812 NM_012275 NP_036407 NM_173170 NP_775262
|
| Function |
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.
|
![Western Blot: IL1F5 Overexpression Lysate (Adult Normal) [NBL1-11924] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IL1F5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4572_IL1F5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11924-img0002.jpg)