HFE2

Gene Symbol	HFE2
Entrez Gene	148738
Alt Symbol	HFE2A, HJV, JH, RGMC
Species	Human
Gene Type	protein-coding
Description	hemochromatosis type 2 (juvenile)
Other Description	RGM domain family member C|haemojuvelin|hemochromatosis type 2 protein|hemojuvelin|repulsive guidance molecule c
Swissprots	Q6ZVN8 Q8WVJ5 Q2PQ63 B1ALI7 Q8NAH2 Q6IMF6
Accessions	ABC40718 CAI22091 CAI22092 CAI22349 CAI22350 CAN86494 CAO00462 CAX62674 CAX86829 CEF39436 EAW71407 EAW71408 EAW71409 Q6ZVN8 AA479148 AK092682 BAC03944 AK092692 BAC03947 AK096905 BAC04890 AK124273 BAC85823 AK223575 AK290831 BAF83520 AK292742 BAF85431 AK315852 BAF98743 AY372521 AAR22390 BC017926 AAH17926 BC085604 AAH85604 DB035674 HQ447765 ADQ32250 XM_005272932 XP_005272989 NM_145277 NP_660320 NM_202004 NP_973733 NM_213652 NP_998817 NM_213653 NP_998818
Function	Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor (By similarity). Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism (By similarity). May cooperate with hepcidin to restrict iron absorption in the gut. Could represent the cellular receptor for hepcidin. {ECO:0000250}.
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Tissue Specificity	Adult and fetal liver, heart, and skeletal muscle. {ECO:0000269|PubMed:14647275}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HFE2 / Hemojuvelin Antibody Blocking Peptide - LS-E19320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HFE2 / Hemojuvelin Antibody Blocking Peptide - LS-E10269 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HFE2 / Hemojuvelin Antibody Blocking Peptide - LS-E10268 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RGM-C/Hemojuvelin Protein - H00148738-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HFE2-Antibody-Center-Blocking-Peptide - BP9699c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HFE2-Antibody-C-term-Blocking-Peptide - BP9699b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human RGM-C/Hemojuvelin, CF - 3720-RG-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln36-Asp400 (mature) & Pro173-Asp400 (C-terminus chain), both with a C-terminal 6-His tag & Gln36-Asp172 (N-terminus chain)

Human HFE2 protein (His Tag) - orb139012 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Cynomolgus HFE2 protein (His Tag) - orb139013 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells

HFE2 Blocking Peptide - 33R-8826 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Hemojuvelin Protein - abx067047 from Abbexa Category Protein Source E.coli Species Human

Human Hemojuvelin Protein - abx067044 from Abbexa Category Protein Source E.coli Species Human

Human Hemojuvelin Protein - abx067046 from Abbexa Category Protein Source E.coli Species Human

HFE2 / Hemojuvelin - H00148738-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HFE2 / Hemojuvelin - H00148738-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Hemojuvelin (HJV), Human - 20-8246 from ARP American Research Products Category Protein Prices $369.00 Sizes 50 µg Source E.coli Species Human

HFE2 fusion protein - ag2354 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human HFE2, His tagged - HFE2-7288H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human Hemochromatosis Type 2 (Juvenile), FLAG-tagged - HFE2-2419H from Creative Biomart Category Protein Source HEK 293 cells.

Recombinant Hemojuvelin (HJV) - RPB995Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Hemojuvelin (HJV) - RPB995Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Hemojuvelin (HJV) - RPB995Hu03 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Hemojuvelin (HJV) - RPB995Hu61 from Uscn Life Science Inc. Category Protein Source 293F cell Species Human

Recombinant Hemojuvelin (HJV) - RPB995Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Hemojuvelin (HJV) - RPB995Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

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