HFE2

Gene Symbol HFE2
Entrez Gene 148738
Alt Symbol HFE2A, HJV, JH, RGMC
Species Human
Gene Type protein-coding
Description hemochromatosis type 2 (juvenile)
Other Description RGM domain family member C|haemojuvelin|hemochromatosis type 2 protein|hemojuvelin|repulsive guidance molecule c
Swissprots Q6ZVN8 Q8WVJ5 Q2PQ63 B1ALI7 Q8NAH2 Q6IMF6
Accessions ABC40718 CAI22091 CAI22092 CAI22349 CAI22350 CAN86494 CAO00462 CAX62674 CAX86829 CEF39436 EAW71407 EAW71408 EAW71409 Q6ZVN8 AA479148 AK092682 BAC03944 AK092692 BAC03947 AK096905 BAC04890 AK124273 BAC85823 AK223575 AK290831 BAF83520 AK292742 BAF85431 AK315852 BAF98743 AY372521 AAR22390 BC017926 AAH17926 BC085604 AAH85604 DB035674 HQ447765 ADQ32250 XM_005272932 XP_005272989 NM_145277 NP_660320 NM_202004 NP_973733 NM_213652 NP_998817 NM_213653 NP_998818
Function Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor (By similarity). Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism (By similarity). May cooperate with hepcidin to restrict iron absorption in the gut. Could represent the cellular receptor for hepcidin. {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Tissue Specificity Adult and fetal liver, heart, and skeletal muscle. {ECO:0000269|PubMed:14647275}.

RGMc CRISPR/Cas9 KO Plasmid (h) - sc-406186 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RGMc HDR Plasmid (h) - sc-406186-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RGMc Double Nickase Plasmid (h) - sc-406186-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RGMc Double Nickase Plasmid (h2) - sc-406186-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RGMc CRISPR Activation Plasmid (h) - sc-406186-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RGMc CRISPR Activation Plasmid (h2) - sc-406186-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RGMc Lentiviral Activation Particles (h) - sc-406186-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RGMc Lentiviral Activation Particles (h2) - sc-406186-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RGMc siRNA (h) - sc-45738 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RGMc shRNA Plasmid (h) - sc-45738-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RGMc shRNA (h) Lentiviral Particles - sc-45738-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RGM-C/Hemojuvelin RNAi - H00148738-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

RGM-C/Hemojuvelin RNAi - H00148738-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU071651 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1140 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1140 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05155 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05155

HFE2 siRNA (Human) - CRJ5591 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RGM-C/Hemojuvelin RNAi - H00148738-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

RGM-C/Hemojuvelin RNAi - H00148738-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

HFE2 - MBS8237397 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HFE2 (NM_145277.4) - SHH311873 from Creative biogene

Category siRNA
Species Reactivities Human

Human HFE2 siRNA - orb276092 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HFE2 shRNA Plasmid (Human) - CHJ5591 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HFE2 miRNA 3'UTR clone - MiUTR3H-09951 from Creative biogene

Species Reactivities Human
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