ULBP2

Gene Symbol	ULBP2
Entrez Gene	80328
Alt Symbol	ALCAN-alpha, N2DL2, NKG2DL2, RAET1H
Species	Human
Gene Type	protein-coding
Description	UL16 binding protein 2
Other Description	NKG2D ligand 2|retinoic acid early transcript 1H
Swissprots	Q9BZM5 Q5VUN4
Accessions	AFP99107 AFP99108 AFP99109 AFP99110 AFP99113 AFP99114 AFP99115 AFP99116 AFP99117 AFP99118 EAW47777 EAW47778 Q9BZM5 AB052906 BAB61048 AF304378 AAK13082 AF321606 AAN39920 AK299895 BAG61739 AX772820 CAE06259 AY026825 AAK07688 AY358665 AAQ89028 BC034689 AAH34689 BG718474 NM_025217 NP_079493
Function	Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Tissue Specificity	Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. {ECO:0000269|PubMed:11444831}.
Top Pathways	Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ULBP2 (6F6) - sc-53135 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

ULBP2 (H-48) - sc-33565 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ULBP2 (N-16) - sc-20569 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ULBP2 antibody - ab88645 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-ULBP2 antibody - ab130591 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ULBP2 antibody [EPR4016(2)] - ab173286 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4016(2)

Anti-ULBP2 antibody [MM0593-7F33] - ab89930 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone MM0593-7F33

Anti-ULBP2 / RAET1H Antibody (aa88-116) - LS-C160425 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ULBP2 / RAET1H Antibody (aa87-116, Biotin) - LS-C224609 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ULBP2 / RAET1H Antibody (aa87-116, AP) - LS-C224607 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ULBP2 / RAET1H Antibody (aa87-116, APC) - LS-C224608 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ULBP2 / RAET1H Antibody (aa87-116, FITC) - LS-C224610 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ULBP2 / RAET1H Antibody (aa87-116, PE) - LS-C224612 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ULBP2 / RAET1H Antibody (aa87-116) - LS-C330275 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ULBP2 / RAET1H Antibody (aa87-116, Azide-free, HRP) - LS-C224611 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

ULBP-2/5/6 Antibody (165903) [Unconjugated] - MAB1298 from Novus Biologicals Prices $99.00, $269.00, $699.00 Sizes 25 µg, 100 µg, 500 µg Host Mouse Clonality Monoclonal Clone 165903

ULBP-2/5/6 Antibody [Unconjugated] - AF1298 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

ULBP-2 Antibody - 27080002 from Novus Biologicals Prices $369.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

ULBP-2 Antibody - H00080328-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

ULBP-2 Antibody (MM0593-7F33) - NBP2-11987 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0593-7F33

ULBP-2/5/6 Antibody (165903) [Phycoerythrin] - FAB1298P from Novus Biologicals Prices $349.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 165903

ULBP-2/5/6 Antibody (165903) [PerCP (Peridinin-chlorophyll Protein Complex)] - FAB1298C from Novus Biologicals Prices $399.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 165903

ULBP-2/5/6 Antibody [Biotin] - BAF1298 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Goat Clonality Polyclonal

ULBP-2/5/6 Antibody (165903) [Allophycocyanin] - FAB1298A from Novus Biologicals Prices $389.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 165903

Rabbit Anti-ULBP2 Polyclonal Antibody - bs-2729R from Bioss Clonality Polyclonal

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