ULBP2

Gene Symbol	ULBP2
Entrez Gene	80328
Alt Symbol	ALCAN-alpha, N2DL2, NKG2DL2, RAET1H
Species	Human
Gene Type	protein-coding
Description	UL16 binding protein 2
Other Description	NKG2D ligand 2|retinoic acid early transcript 1H
Swissprots	Q9BZM5 Q5VUN4
Accessions	AFP99107 AFP99108 AFP99109 AFP99110 AFP99113 AFP99114 AFP99115 AFP99116 AFP99117 AFP99118 EAW47777 EAW47778 Q9BZM5 AB052906 BAB61048 AF304378 AAK13082 AF321606 AAN39920 AK299895 BAG61739 AX772820 CAE06259 AY026825 AAK07688 AY358665 AAQ89028 BC034689 AAH34689 BG718474 NM_025217 NP_079493
Function	Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Tissue Specificity	Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. {ECO:0000269|PubMed:11444831}.
Top Pathways	Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ULBP2 full length protein - ab151636 from Abcam Category Protein Source HEK 293 cells Species Human

Human ULBP2 full length protein - ab128443 from Abcam Category Protein Source E. coli Species Human

Human ULBP2 full length protein - ab184602 from Abcam Category Protein Source E. coli Species Human

Human ULBP2 full length protein - ab185428 from Abcam Category Protein Source Mammalian Species Human

ULBP2 / RAET1H Antibody Blocking Peptide - LS-E4717 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULBP-2 Recombinant Protein - H00080328-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ULBP-2 Protein - NBP1-98937 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

ULBP2-Antibody-Center-Blocking-Peptide - BP17088c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human ULBP-2 Fc Chimera, CF - 1298-UL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human ALCAN alpha protein - orb84669 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human ULBP2 protein - orb49560 from Biorbyt Category Protein Prices $238.00, $476.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human ULBP2 protein - orb169524 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human ALCAN alpha protein - orb84670 from Biorbyt Category Protein Prices $400.00, $527.00 Sizes 50 μg, 100 μg Source Human Species Human

ULBP2 protein (His tag) - 80R-2332 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

ULBP2 / NKG2D ligand 2 (26-216, His-tag) - AR50416PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

ULBP2 / NKG2D ligand 2 (26-216, His-tag) - AR50416PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

ULBP2 / NKG2D ligand 2 - H00080328-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

NKG2D Ligand 2, N2DL2, Human, Recombinant - 19-C508 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

ULBP2, 26-216aa, Human, His tag, E.coli - 01-P1592 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ULBP2 fusion protein - Ag3798 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

ULBP2 Human - PRPS-1141 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

Recombinant Human N2DL2 Protein - BP001762-C508 from Syd Labs Category Protein Prices $98.00, $252.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human N2DL2 Protein - BP001762-PRO-1134 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

ULBP2, 26-216aa, Recombinant Protein - GWB-P0446D from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human ULBP2, His tagged - ULBP2-5185H from Creative Biomart Category Protein Source Human Cells Species Human

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