ULBP2

Gene Symbol ULBP2
Entrez Gene 80328
Alt Symbol ALCAN-alpha, N2DL2, NKG2DL2, RAET1H
Species Human
Gene Type protein-coding
Description UL16 binding protein 2
Other Description NKG2D ligand 2|retinoic acid early transcript 1H
Swissprots Q9BZM5 Q5VUN4
Accessions AFP99107 AFP99108 AFP99109 AFP99110 AFP99113 AFP99114 AFP99115 AFP99116 AFP99117 AFP99118 EAW47777 EAW47778 Q9BZM5 AB052906 BAB61048 AF304378 AAK13082 AF321606 AAN39920 AK299895 BAG61739 AX772820 CAE06259 AY026825 AAK07688 AY358665 AAQ89028 BC034689 AAH34689 BG718474 NM_025217 NP_079493
Function Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Tissue Specificity Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. {ECO:0000269|PubMed:11444831}.
Top Pathways Natural killer cell mediated cytotoxicity

ULBP2 CRISPR/Cas9 KO Plasmid (h) - sc-403663 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP2 HDR Plasmid (h) - sc-403663-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP2 Double Nickase Plasmid (h) - sc-403663-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP2 Double Nickase Plasmid (h2) - sc-403663-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP2 CRISPR Activation Plasmid (h) - sc-403663-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP2 CRISPR Activation Plasmid (h2) - sc-403663-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP2 Lentiviral Activation Particles (h) - sc-403663-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP2 Lentiviral Activation Particles (h2) - sc-403663-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP2 siRNA (h) - sc-44564 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ULBP2 shRNA Plasmid (h) - sc-44564-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ULBP2 shRNA (h) Lentiviral Particles - sc-44564-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU107261 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22484 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22484 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05147 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05147

ULBP2 siRNA (Human) - CRJ2859 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ULBP-2 RNAi - H00080328-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ULBP2 - MBS8229839 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ULBP2 (NM_025217.2) - SHH440364 from Creative biogene

Category siRNA
Species Reactivities Human

Human ULBP2 siRNA - orb273360 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ULBP2 shRNA Plasmid (Human) - CHJ2859 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ULBP2 miRNA 3'UTR clone - MiUTR1H-11002 from Creative biogene

Species Reactivities Human
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