ULBP2

Gene Symbol	ULBP2
Entrez Gene	80328
Alt Symbol	ALCAN-alpha, N2DL2, NKG2DL2, RAET1H
Species	Human
Gene Type	protein-coding
Description	UL16 binding protein 2
Other Description	NKG2D ligand 2|retinoic acid early transcript 1H
Swissprots	Q9BZM5 Q5VUN4
Accessions	AFP99107 AFP99108 AFP99109 AFP99110 AFP99113 AFP99114 AFP99115 AFP99116 AFP99117 AFP99118 EAW47777 EAW47778 Q9BZM5 AB052906 BAB61048 AF304378 AAK13082 AF321606 AAN39920 AK299895 BAG61739 AX772820 CAE06259 AY026825 AAK07688 AY358665 AAQ89028 BC034689 AAH34689 BG718474 NM_025217 NP_079493
Function	Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Tissue Specificity	Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. {ECO:0000269|PubMed:11444831}.
Top Pathways	Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-ULBP2-cDNA-Clone - DC06775 from Abgent, a WuXi AppTec company Prices $332.10 Sizes 10 µg Species Human Accession BC034689

Human ULBP-2 (NP_079493) VersaClone cDNA - RDC0822 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

ULBP2 - MBS1277645 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC034689

Human ULBP2 cDNA clone(NM_025217.2) - CDFG005002 from Creative Biomart Species Human Accession NM_025217.2

human ULBP2 ORF clone - CDCH098140 from Creative Biomart Species Human Accession NM_025217

human ULBP2 ORF clone - CDCH098141 from Creative Biomart Species Human Accession NM_025217

Human ULBP2 ORF Clone(NM_025217.2) - CDCL180521 from Creative Biomart Species Human Accession NM_025217.2

Human ULBP2 ORF Clone(NM_025217.2) - CDCR310300 from Creative Biomart Species Human Accession NM_025217.2

Human ULBP2 ORF Clone(NM_025217.2) - CDCR310341 from Creative Biomart Species Human Accession NM_025217.2

Human ULBP2 ORF Clone(NM_025217.2) - CDCR310356 from Creative Biomart Species Human Accession NM_025217.2

Human ULBP2 Gene ORF cDNA clone in cloning vector - HG12143-G from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12143-ACR from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, C-His tag - HG12143-CH from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12143-NF from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12143-NM from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12143-CF from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12143-CM from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG12143-CY from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12143-ACG from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid - HG12143-UT from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG12143-NY from Sino Biological Species Human

Human ULBP2 Gene ORF cDNA clone expression plasmid, N-His tag - HG12143-NH from Sino Biological Species Human

Human ULBP2 ORF Clone(NM_025217.2) - CDCR310300 from Creative biogene Species Human

Human ULBP2 ORF Clone (BC034689) - CDCS415932 from Creative biogene Species Human Accession Q9BZM5

Human ULBP2 ORF clone (BC034689) - CDCB160016 from Creative biogene Species Human

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