CLDN1

Gene Symbol	CLDN1
Entrez Gene	9076
Alt Symbol	CLD1, ILVASC, SEMP1
Species	Human
Gene Type	protein-coding
Description	claudin 1
Other Description	claudin-1|senescence-associated epithelial membrane protein 1
Swissprots	O95832
Accessions	AAK20945 EAW78107 EAW78108 O95832 AA484795 AF086514 AF101051 AAD16433 AF114837 AAP97236 AF115546 AAD22962 AF134160 AAF61393 AK225963 AK296934 BAG59485 AK312866 BAG35718 AY358652 AAQ89015 BC012471 AAH12471 CR457138 CAG33419 DA907275 DQ891457 ABM82383 DQ896823 ABM87822 EF564137 ABQ42705 NM_021101 NP_066924
Function	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells. {ECO:0000269|PubMed:23407391}.
Subcellular Location	Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. {ECO:0000269|PubMed:9931503}.
Top Pathways	Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Pathogenic Escherichia coli infection, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLDN1 / Claudin 1 ELISA Kit (Sandwich ELISA) - LS-F6509 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat CLDN1 / Claudin 1 ELISA Kit (Cell-Based ELISA) - LS-F1886 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Rat CLDN1 / Claudin 1 ELISA Kit (Sandwich ELISA) - LS-F9865 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 31 pg/ml Range 0.156-10 ng/ml

Human Claudin 1 ELISA Kit - abx151081 from Abbexa Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 ng/ml - 10 ng/ml

Claudin 1 (CLDN1), Human, ELISA Kit - SEC388Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.059ng/mL Range 0.156-10ng/mL

Claudin 1, Human, ELISA Kit - E01C0381 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/mL,

Claudin-1 (CLDN1), Human, ELISA Kit - CSB-EL005490HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Claudin 1, CLDN1, Human, ELISA Kit - E-EL-H0745 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Claudin 1, CLDN1, Rabbit, ELISA Kit - E-EL-RB0835 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Claudin 1, CLDN1, Chicken, ELISA Kit - E-EL-Ch0127 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Claudin 1, CLDN1, Porcine, ELISA Kit - E-EL-P1652 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Claudin 1, CLDN1, Sheep, ELISA Kit - E-EL-S0630 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Claudin 1, CLDN1, Monkey, ELISA Kit - E-EL-MK1862 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CLDN1 (Human) IP-WB Antibody Pair - H00009076-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

CLDN1 (Human) IP-WB Antibody Pair - H00009076-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

CLDN1 (Human) IP-WB Antibody Pair - H00009076-PW3 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

CLDN1 (Human) Matched Antibody Pair - H00009076-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human CLDN1 ELISA Kit - HC0388 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CLDN1 ELISA Kit - AC0388 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Claudin 1 Colorimetric Cell-Based ELISA Kit - CB5141 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human CLDN1(Claudin 1) ELISA Kit - E-EL-H0745 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human CLDN1 (Claudin 1) CLIA Kit - E-CL-H0538 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

Claudin 1, ELISA Kit - MBS724224 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Claudin 1, ELISA Kit - MBS007425 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Claudin 1, ELISA Kit - MBS737793 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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