CLDN1

Gene Symbol	CLDN1
Entrez Gene	9076
Alt Symbol	CLD1, ILVASC, SEMP1
Species	Human
Gene Type	protein-coding
Description	claudin 1
Other Description	claudin-1|senescence-associated epithelial membrane protein 1
Swissprots	O95832
Accessions	AAK20945 EAW78107 EAW78108 O95832 AA484795 AF086514 AF101051 AAD16433 AF114837 AAP97236 AF115546 AAD22962 AF134160 AAF61393 AK225963 AK296934 BAG59485 AK312866 BAG35718 AY358652 AAQ89015 BC012471 AAH12471 CR457138 CAG33419 DA907275 DQ891457 ABM82383 DQ896823 ABM87822 EF564137 ABQ42705 NM_021101 NP_066924
Function	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells. {ECO:0000269|PubMed:23407391}.
Subcellular Location	Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. {ECO:0000269|PubMed:9931503}.
Top Pathways	Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Pathogenic Escherichia coli infection, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Claudin 1 full length protein - ab152949 from Abcam Category Protein Source Wheat germ Species Human

CLDN1 / Claudin 1 Antibody Blocking Peptide - LS-E8198 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLDN1 / Claudin 1 Antibody Blocking Peptide - LS-E8197 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLDN1 / Claudin 1 Antibody Blocking Peptide - LS-E11892 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLDN1 / Claudin 1 Antibody Blocking Peptide - LS-E30709 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Claudin-1 Protein - H00009076-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Claudin-1 Blocking Peptide - NBP1-77036PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Claudin-1-CLDN1-Antibody-Loop2-Blocking-peptide - BP6308b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Claudin-1-CLDN1-Antibody-Loop1-Blocking-peptide - BP6308a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Claudin 1 Blocking Peptide - 33R-3488 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Claudin 1 Blocking Peptide - abx063543 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Sheep

Claudin-1 / CLDN1 - H00009076-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Claudin-1 / CLDN1 - H00009076-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Claudin-1 / CLDN1 Control Peptide - AP30236CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CLDN1 Peptide - 5187P from ProSci Category Peptide Species Human

Claudin 1 fusion protein - ag15931 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Claudin 1 fusion protein - Ag3713 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CLDN1, GST-tagged - CLDN1-11283H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Claudin 1 (CLDN1) - RPC388Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Claudin 1 (CLDN1) - RPC388Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Claudin-1 (CLDN1) - PAN-63801 from Nordic BioSite Category Protein

Claudin 1 Blocking Peptide - CBP2349 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Sheep

Claudin-1 (R197) Peptide - BS1063P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Claudin 1 (CLDN1) - RPC388Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Claudin 1 Protein (Recombinant) - abx166956 from Abbexa Category Protein Source Human Species Human

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