CLDN1

Gene Symbol	CLDN1
Entrez Gene	9076
Alt Symbol	CLD1, ILVASC, SEMP1
Species	Human
Gene Type	protein-coding
Description	claudin 1
Other Description	claudin-1|senescence-associated epithelial membrane protein 1
Swissprots	O95832
Accessions	AAK20945 EAW78107 EAW78108 O95832 AA484795 AF086514 AF101051 AAD16433 AF114837 AAP97236 AF115546 AAD22962 AF134160 AAF61393 AK225963 AK296934 BAG59485 AK312866 BAG35718 AY358652 AAQ89015 BC012471 AAH12471 CR457138 CAG33419 DA907275 DQ891457 ABM82383 DQ896823 ABM87822 EF564137 ABQ42705 NM_021101 NP_066924
Function	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells. {ECO:0000269|PubMed:23407391}.
Subcellular Location	Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. {ECO:0000269|PubMed:9931503}.
Top Pathways	Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Pathogenic Escherichia coli infection, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CLDN1-Over-expression-Lysate - LY11282a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CLDN1 293T Cell Transient Overexpression Lysate(Denatured) - H00009076-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CLDN1 HEK293 Cell Transient Overexpression Lysate (Non-Denatured) - L037T6 from Acris Antibodies Category Cell Lysate Prices $290.00 Sizes 100 µg

CLDN1 293 Cell Lysate - 402466 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Claudin-1 Overexpression Lysate (Native) - NBL1-09235 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

claudin-1 (h): 293T Lysate - sc-113827 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

claudin-1 (h2): 293T Lysate - sc-176724 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CLDN1 Over-expression Lysate Product - GWB-E471E6 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Claudin-1 Overexpression Lysate (Denatured) - H00009076-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Claudin-1 Overexpression Lysate (Denatured) - H00009076-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human CLDN1 Knockdown Stable Cell Line - CSC-DC003223 from Creative biogene Category Cell Line Species Human

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