CLDN1
| Gene Symbol | CLDN1 |
|---|---|
| Entrez Gene | 9076 |
| Alt Symbol | CLD1, ILVASC, SEMP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | claudin 1 |
| Other Description | claudin-1|senescence-associated epithelial membrane protein 1 |
| Swissprots | O95832 |
| Accessions | AAK20945 EAW78107 EAW78108 O95832 AA484795 AF086514 AF101051 AAD16433 AF114837 AAP97236 AF115546 AAD22962 AF134160 AAF61393 AK225963 AK296934 BAG59485 AK312866 BAG35718 AY358652 AAQ89015 BC012471 AAH12471 CR457138 CAG33419 DA907275 DQ891457 ABM82383 DQ896823 ABM87822 EF564137 ABQ42705 NM_021101 NP_066924 |
| Function | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells. {ECO:0000269|PubMed:23407391}. |
| Subcellular Location | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. {ECO:0000269|PubMed:9931503}. |
| Top Pathways | Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Pathogenic Escherichia coli infection, Hepatitis C |
claudin-1 CRISPR/Cas9 KO Plasmid (h) - sc-400609 from Santa Cruz Biotechnology
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claudin-1 HDR Plasmid (h) - sc-400609-HDR from Santa Cruz Biotechnology
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claudin-1 Double Nickase Plasmid (h) - sc-400609-NIC from Santa Cruz Biotechnology
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claudin-1 Double Nickase Plasmid (h2) - sc-400609-NIC-2 from Santa Cruz Biotechnology
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claudin-1 CRISPR Activation Plasmid (h) - sc-400609-ACT from Santa Cruz Biotechnology
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claudin-1 CRISPR Activation Plasmid (h2) - sc-400609-ACT-2 from Santa Cruz Biotechnology
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claudin-1 Lentiviral Activation Particles (h) - sc-400609-LAC from Santa Cruz Biotechnology
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claudin-1 Lentiviral Activation Particles (h2) - sc-400609-LAC-2 from Santa Cruz Biotechnology
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claudin-1 siRNA (h) - sc-43040 from Santa Cruz Biotechnology
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claudin-1 shRNA Plasmid (h) - sc-43040-SH from Santa Cruz Biotechnology
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claudin-1 shRNA (h) Lentiviral Particles - sc-43040-V from Santa Cruz Biotechnology
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Claudin-1 RNAi - H00009076-R01 from Novus Biologicals
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MISSION® esiRNA - EHU017501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6171 from Sigma-Aldrich
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CLDN1 siRNA (Human) - CRH5992 from Cohesion Biosciences
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CLDN1 - MBS8215949 from MyBioSource
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claudin-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400609-KO-2 from Santa Cruz Biotechnology
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claudin-1 HDR Plasmid (h2) - sc-400609-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CLDN1 (NM_021101.4) - SHH264621 from Creative biogene
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CLDN1 shRNA Plasmid (Human) - CHH5992 from Cohesion Biosciences
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CLDN1 miRNA 3'UTR clone - MiUTR4H-TG02142 from Creative biogene
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