CLDN1

Gene Symbol CLDN1
Entrez Gene 9076
Alt Symbol CLD1, ILVASC, SEMP1
Species Human
Gene Type protein-coding
Description claudin 1
Other Description claudin-1|senescence-associated epithelial membrane protein 1
Swissprots O95832
Accessions AAK20945 EAW78107 EAW78108 O95832 AA484795 AF086514 AF101051 AAD16433 AF114837 AAP97236 AF115546 AAD22962 AF134160 AAF61393 AK225963 AK296934 BAG59485 AK312866 BAG35718 AY358652 AAQ89015 BC012471 AAH12471 CR457138 CAG33419 DA907275 DQ891457 ABM82383 DQ896823 ABM87822 EF564137 ABQ42705 NM_021101 NP_066924
Function Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells. {ECO:0000269|PubMed:23407391}.
Subcellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Tissue Specificity Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. {ECO:0000269|PubMed:9931503}.
Top Pathways Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Pathogenic Escherichia coli infection, Hepatitis C

Claudin-1 (D5H1D) XP ® Rabbit mAb - 13255 from Cell Signaling Technology

Prices $109.00, $282.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5H1D
Western blot analysis of extracts from A431 and MCF7 cells using Claudin-1 (D5H1D) XP ® Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

Claudin-1 Antibody - 4933 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A431 and ZR-75 cells using Claudin-1 Antibody.

Claudin-1 (D3H7C) Rabbit mAb - 13995 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3H7C
Western blot analysis of extracts from IGROV-1, A549, and 293 cells using Claudin-1 (D3H7C) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

claudin-1 (A-9) - sc-166338 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
claudin-1 (A-9): sc-166338. Western blot analysis of claudin-1 expression in non-transfected 293T: sc-117752 (A), human claudin-1 transfected 293T: sc-113827 (B) and SCC-4 (C) whole cell lysates.

claudin-1 (A-10) - sc-22932 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
claudin-1 (A-10): sc-22932. Western blot analysis of claudin-1 expression in SCC-4 whole cell lysate.

claudin-1 (D-4) - sc-137121 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Claudin-1 (D-4): sc-137121. Western blot analysis of Claudin-1 expression in non-transfected: sc-117752 (A) and mouse Claudin-1 transfected: sc-113827 (B) 293T whole cell lysates.

claudin-1 (C-18) - sc-17658 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
claudin-1 (C-18): sc-17658. Immunofluorescence staining of formalin-fixed Hep G2 cells showing membrane localization.

claudin-1 (XX7) - sc-81796 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
claudin-1 (XX7): sc-81796. Western blot analysis of claudin-1 expression in non-transfected 293T: sc-117752 (A), human claudin-1 transfected 293T: sc-113827 (B) and SCC-4 (C) whole cell lysates.

claudin-1/2 (FL-211) - sc-28668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Claudin 1 antibody - ab15098 from Abcam

Prices $400.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Human skin stained with ab15098.

Anti-Claudin 1 antibody - ab56417 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Claudin 1 antibody (ab56417) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.

Anti-Claudin 1 antibody - ab79404 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Claudin 1 antibody (ab79404) at 1/500 dilutionLane 1 : HeLa cell extract treated with Hu (2nM, 24hours)Lane 2 : HeLa cell extract treated with Hu (2nM, 24hours) with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Claudin 1 antibody - ab140349 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human skin labelling Claudin 1 using ab140349 at 1/50 dilution.

Anti-Claudin 1 antibody - ab53020 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Claudin 1 antibody (ab53020) at 1/500 dilutionLane 1 : Extracts from HeLa cells with no immunizing peptideLane 2 : Extracts from HeLa cells with immunizing peptide

Anti-Claudin 1 antibody [1C5-D9] - ab115225 from Abcam

Prices $385.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C5-D9
Human breast (formalin fixed, paraffin embedded) stained with ab115225 at 5 ug/ml.

Anti-Claudin 1 antibody [EPR9306] - ab180158 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9306
Anti-Claudin 1 antibody [EPR9306] (ab180158) at 1/2000 dilution + Human fetal liver lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab136636) at 1/500 dilution

Anti-Claudin 1 antibody, prediluted - ab15099 from Abcam

Prices $379.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Human skin stained with ab15099.

Anti-Claudin 1 antibody - C-terminal - ab200808 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Claudin 1 antibody - Loop 1 - ab63070 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Claudin 1 antibody - Loop 1 (ab63070) at 1/60 dilution + Jurkat cell lysates at 35 µg

Anti-CLDN1 / Claudin 1 Antibody (aa162-211) - LS-C118352 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa cells, treated with Hu 2 nM 24h, using Claudin 1 (Ab-210) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CLDN1 / Claudin 1 Antibody (Loop 1) - LS-C100053 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hCLDN1-Loop1 , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-CLDN1 / Claudin 1 Antibody - LS-C202928 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CLDN1 / Claudin 1 Antibody (Loop1, AP) - LS-C243987 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLDN1 / Claudin 1 Antibody (Loop1, APC) - LS-C243988 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLDN1 / Claudin 1 Antibody (Loop1, PE) - LS-C243994 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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