UBA3

Gene Symbol UBA3
Entrez Gene 9039
Alt Symbol NAE2, UBE1C, hUBA3
Species Human
Gene Type protein-coding
Description ubiquitin-like modifier activating enzyme 3
Other Description NEDD8-activating enzyme E1 catalytic subunit|NEDD8-activating enzyme E1 subunit 2|NEDD8-activating enzyme E1C|Nedd8-activating enzyme hUba3|UBA3, ubiquitin-activating enzyme E1 homolog|ubiquitin-activating enzyme 3|ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)|ubiquitin-activating enzyme E1C (homologous to yeast UBA3)|ubiquitin-like modifier-activating enzyme 3
Swissprots Q9NTU3 O76088 A8K027 Q8TBC4 A6NLB5
Accessions CDM22118 EAW65470 Q8TBC4 AB012190 BAA33144 AF046024 AAC27648 AK002159 BAG51021 AK289392 BAF82081 AK298878 BAH12892 AK314751 BAG37290 AK316540 BAH14911 AL117566 CAB55996 AM392893 CAL37771 AM393088 CAL37966 BC022853 AAH22853 BG940987 CD700642 CR533537 CAG38568 DQ893167 ABM84093 DQ896465 ABM87464 XM_011534210 XP_011532512 XM_011534211 XP_011532513 NM_003968 NP_003959 NM_198195 NP_937838 NM_198197
Function Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10207026}.
Top Pathways Ubiquitin mediated proteolysis

UBA3 (E-5) - sc-377272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBA3 (E-5): sc-377272. Western blot analysis of UBA3 expression in mouse brain tissue extract (A) and Hep G2 (B), HeLa (C), RAW 264.7 (D) and K-562 (E) whole cell lysates.

UBA3 (F-10) - sc-377212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBA3 (F-10): sc-377212. Western blot analysis of UBA3 expression in mouse brain tissue extract (A) and SK-N-MC (B) and Hep G2 (C) whole cell lysates.

UBA3 (B-10) - sc-377352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBA3 (B-10): sc-377352. Western blot analysis of UBA3 expression in mouse brain tissue extract (A) and Hep G2 whole cell lysate (B).

UBA3 (N-18) - sc-79800 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UBA3 (N-18): sc-79800. Western blot analysis of UBA3 expression in mouse brain tissue extract.

UBA3 (K-17) - sc-79798 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UBA3 (H-147) - sc-292599 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

UBA3 (E-22) - sc-130905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
UBA3 (E-22): sc-130905. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.

Anti-UBE1C antibody - ab177112 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human hepatocarcinoma tissue labeling UBE1C with ab177112 at 1/100.

Anti-UBE1C antibody - ab38649 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-UBE1C antibody (ab38649) + mouse brain tissue lysate

Anti-UBE1C antibody - ab127179 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-UBE1C antibody (ab127179) at 1/3000 dilution + A431 whole cell lysate at 30 µg

Anti-UBE1C antibody [MILR42872] - ab124728 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone MILR42872
All lanes : Anti-UBE1C antibody [MILR42872] (ab124728)Lane 1 : Fetal lung cell lysateLane 2 : 293T cell lysateLane 3 : HeLa cell lysateLane 4 : RAW 264.7 cell lysateLane 5 : HepG2 cell lysateLane 6 : K562 cell lysateLysates/proteins at 10 µg per lane.

Anti-UBA3 / UBE1C Antibody (C-Terminus, AP) - LS-C220991 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA3 / UBE1C Antibody (C-Terminus, APC) - LS-C220994 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA3 / UBE1C Antibody (C-Terminus, Biotin) - LS-C220995 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA3 / UBE1C Antibody (C-Terminus, FITC) - LS-C220996 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA3 / UBE1C Antibody (C-Terminus, PE) - LS-C220998 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA3 / UBE1C Antibody (C-Terminus, Azide-free, HRP) - LS-C220997 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA3 / UBE1C Antibody (C-Terminus) - LS-C328997 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA3 / UBE1C Antibody (aa35-84) - LS-C111278 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UBA3 / UBE1C antibody LS-C111278 Western blot of Fetal Pancreas lysate.

Anti-UBA3 / UBE1C Antibody - LS-C155556 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE UBA3 / UBE1C antibody diluted at 1:3000

Anti-UBA3 / UBE1C Antibody (aa415-445) - LS-C96599 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

UBA3 Antibody - NBP1-83150 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UBA3 Antibody (MILR42872) - NBP1-95191 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone MILR42872
Western Blot: UBA3 Antibody (MILR42872) [NBP1-95191] (A) fetal lung, (B) 293T, © HeLa, (D) RAW 264.7, (E) HepG2, and (F) K562 lysates.

UBA3 Antibody - NBP2-20777 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UBA3 Antibody [NBP2-20777] - Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE gel, diluted at 1:3000.

Anti-UBE1C (N-term) antibody produced in rabbit - SAB1300144 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-UBE1C (N-term) Antibody: <B>Cat. No. SAB1300144</B>: UBE1C in mouse heart tissue lysates with Anti-UBE1C (N-term) Antibody at 4.0 μg/mL.
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