UBA3

Gene Symbol UBA3
Entrez Gene 9039
Alt Symbol NAE2, UBE1C, hUBA3
Species Human
Gene Type protein-coding
Description ubiquitin-like modifier activating enzyme 3
Other Description NEDD8-activating enzyme E1 catalytic subunit|NEDD8-activating enzyme E1 subunit 2|NEDD8-activating enzyme E1C|Nedd8-activating enzyme hUba3|UBA3, ubiquitin-activating enzyme E1 homolog|ubiquitin-activating enzyme 3|ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)|ubiquitin-activating enzyme E1C (homologous to yeast UBA3)|ubiquitin-like modifier-activating enzyme 3
Swissprots Q9NTU3 O76088 A8K027 Q8TBC4 A6NLB5
Accessions CDM22118 EAW65470 Q8TBC4 AB012190 BAA33144 AF046024 AAC27648 AK002159 BAG51021 AK289392 BAF82081 AK298878 BAH12892 AK314751 BAG37290 AK316540 BAH14911 AL117566 CAB55996 AM392893 CAL37771 AM393088 CAL37966 BC022853 AAH22853 BG940987 CD700642 CR533537 CAG38568 DQ893167 ABM84093 DQ896465 ABM87464 XM_011534210 XP_011532512 XM_011534211 XP_011532513 NM_003968 NP_003959 NM_198195 NP_937838 NM_198197
Function Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10207026}.
Top Pathways Ubiquitin mediated proteolysis

NEDD8-activating enzyme E1 catalytic subunit, UBA3, Human, ELISA Kit - E1027h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.156-10 ng/mL

ubiquitin-like modifier activating enzyme 3, ELISA Kit - MBS9318304 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human UBA3 / UBE1C ELISA Kit (Custom ELISA) - LS-F15668 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Mouse UBA3 / UBE1C ELISA Kit (Custom ELISA) - LS-F15666 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Rat UBA3 / UBE1C ELISA Kit (Custom ELISA) - LS-F15667 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Human NEDD8-activating enzyme E1 catalytic subunit ELISA Kit - abx250401 from Abbexa

Category ELISA Kit
Range 0.156 ng/ml - 10 ng/ml

Human NEDD8-activating enzyme E1 catalytic subunit ELISA Kit - EKE53739 from Biomatik

Category ELISA Kit
Prices $685.40, $2,912.95, $5,483.20
Sizes 96 t, 5x96t, 10x96t
Sensitivity The minimum detectable dose of this kit is typically less than 0.081 ng/mL
Range 0.156-10 ng/mL

UBA3 - EKH2300 from Nordic BioSite

Sensitivity 0.094ng/ml
Range 0.156-10ng/ml

Human UBA3 ELISA Kit - E025916 from Biobool

Category ELISA Kit

UBA3 ELISA Kit (Human) (OKEH04416) - OKEH04416 from Aviva Systems Biology

Category ELISA Kit
Prices $596.00
Sizes 96 wells
Sensitivity < 0.07 ng/mL
Range 0.15 - 10 ng/mL

NEDD8-activating enzyme E1 catalytic subunit, ELISA Kit - MBS2881434 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 0.156-10 ng/mL

NEDD8-activating enzyme E1 catalytic subunit, ELISA Kit - MBS762608 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/ml
Range 0.156-10ng/ml

Human UBA3 / UBE1C ELISA Kit (Sandwich ELISA) - LS-F33709 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 0.094
Range 0.156-10 ng/ml
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