UBA3

Gene Symbol UBA3
Entrez Gene 9039
Alt Symbol NAE2, UBE1C, hUBA3
Species Human
Gene Type protein-coding
Description ubiquitin-like modifier activating enzyme 3
Other Description NEDD8-activating enzyme E1 catalytic subunit|NEDD8-activating enzyme E1 subunit 2|NEDD8-activating enzyme E1C|Nedd8-activating enzyme hUba3|UBA3, ubiquitin-activating enzyme E1 homolog|ubiquitin-activating enzyme 3|ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)|ubiquitin-activating enzyme E1C (homologous to yeast UBA3)|ubiquitin-like modifier-activating enzyme 3
Swissprots Q9NTU3 O76088 A8K027 Q8TBC4 A6NLB5
Accessions CDM22118 EAW65470 Q8TBC4 AB012190 BAA33144 AF046024 AAC27648 AK002159 BAG51021 AK289392 BAF82081 AK298878 BAH12892 AK314751 BAG37290 AK316540 BAH14911 AL117566 CAB55996 AM392893 CAL37771 AM393088 CAL37966 BC022853 AAH22853 BG940987 CD700642 CR533537 CAG38568 DQ893167 ABM84093 DQ896465 ABM87464 XM_011534210 XP_011532512 XM_011534211 XP_011532513 NM_003968 NP_003959 NM_198195 NP_937838 NM_198197
Function Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10207026}.
Top Pathways Ubiquitin mediated proteolysis

UBA3-Over-expression-Lysate - LY11883a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag UBA3 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the UBA3 gene

UBA3 overexpression lysate - LY404973 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

UBA3 293 Cell Lysate - 408539 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

UBA3 293 Cell Lysate - 403497 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

UBA3 Overexpression Lysate (Native) - NBL1-17497 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: UBA3 Overexpression Lysate (Adult Normal) [NBL1-17497] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UBA3.

UBA3 Overexpression Lysate (Native) - NBL1-17498 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: UBA3 Overexpression Lysate (Adult Normal) [NBL1-17498] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UBA3.

UBA3 Over-expression Lysate Product - GWB-CBA92F from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

UBA3 Over-expression Lysate Product - GWB-70C7F3 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

Panoply™ Human UBA3 Knockdown Stable Cell Line - CSC-DC016931 from Creative biogene

Category Cell Line
Species Human
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