UBA3

Gene Symbol	UBA3
Entrez Gene	9039
Alt Symbol	NAE2, UBE1C, hUBA3
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like modifier activating enzyme 3
Other Description	NEDD8-activating enzyme E1 catalytic subunit|NEDD8-activating enzyme E1 subunit 2|NEDD8-activating enzyme E1C|Nedd8-activating enzyme hUba3|UBA3, ubiquitin-activating enzyme E1 homolog|ubiquitin-activating enzyme 3|ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)|ubiquitin-activating enzyme E1C (homologous to yeast UBA3)|ubiquitin-like modifier-activating enzyme 3
Swissprots	Q9NTU3 O76088 A8K027 Q8TBC4 A6NLB5
Accessions	CDM22118 EAW65470 Q8TBC4 AB012190 BAA33144 AF046024 AAC27648 AK002159 BAG51021 AK289392 BAF82081 AK298878 BAH12892 AK314751 BAG37290 AK316540 BAH14911 AL117566 CAB55996 AM392893 CAL37771 AM393088 CAL37966 BC022853 AAH22853 BG940987 CD700642 CR533537 CAG38568 DQ893167 ABM84093 DQ896465 ABM87464 XM_011534210 XP_011532512 XM_011534211 XP_011532513 NM_003968 NP_003959 NM_198195 NP_937838 NM_198197
Function	Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10207026}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBE1C full length protein - ab140421 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human UBE1C full length protein - ab123194 from Abcam Category Protein Source E. coli Species Human

UBA3 / UBE1C Antibody Blocking Peptide - LS-E364 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBA3 / UBE1C Antibody Blocking Peptide - LS-E18226 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBA3 Recombinant Protein - H00009039-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UBA3 Protein - NBP1-99094 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

UBA3 Peptide - P0179 from Novus Biologicals Category Peptide Species Human

UBE1C-Antibody-C-term-Blocking-Peptide - BP1063b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human UBA3 protein - orb169499 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

UBA3 Blocking Peptide - 33R-2446 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBA3 protein (His tag) - 80R-2169 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

UBA3 / UBE1C (1-463, His-tag) - AR50250PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

UBA3 / UBE1C (1-463, His-tag) - AR50250PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

UBA3 / UBE1C - H00009039-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBA3 / UBE1C - H00009039-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UBA3, 1-463aa, Human, His tag, E.coli - 01-P1425 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

UBA3 fusion protein - ag4831 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

UBA3 Human - ENPS-583 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Ubiquitin-Like Modifier Activating Enzyme 3 Enzyme - BP002819-ENZ-576 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

Recombinant UBA3 protein - 31234 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

UBA3, 1-463aa, Recombinant Protein - GWB-P0613B from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Ubiquitin-Like Modifier Activating Enzyme 3, His-tagged - UBA3-1938H from Creative Biomart Category Protein

Recombinant Human UBA3, GST-tagged - UBA3-254H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

UBA3 1-463aa - CMB-1258 from Reagent Proteins Category Protein Prices $469.00, $889.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

UBA3(UBE1C), protein-GST fusion - 009-001-U26 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

Search more