LAT

Gene Symbol	LAT
Entrez Gene	27040
Alt Symbol	LAT1, pp36
Species	Human
Gene Type	protein-coding
Description	linker for activation of T cells
Other Description	36 kDa phospho-tyrosine adapter protein|36 kDa phospho-tyrosine adaptor protein|linker for activation of T cells, transmembrane adaptor|linker for activation of T-cells family member 1|p36-38
Swissprots	O43919 B7WPI0 O43561 C7C5T6 G5E9K3
Accessions	EAW52024 EAW52025 EAW52026 EAW52027 EAW52028 EAW52029 EAW52030 EAW52031 O43561 AF036905 AAC39636 AF036906 AAC39637 AJ223280 CAA11218 AK093815 AK307342 BC011563 AAH11563 BI769296 BI911769 FN432831 CBA11532 FN432832 CBA11533 FN432833 CBA11534 FN432834 CBA11535 NM_001014987 NP_001014987 NM_001014988 NP_001014988 NM_001014989 NP_001014989 NM_014387 NP_055202
Function	Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts.
Tissue Specificity	Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). {ECO:0000269|PubMed:16160011, ECO:0000269|PubMed:9489702}.
Top Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-LAT (Tyr171) Antibody - 3581 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Phospho-LAT (Tyr191) Antibody - 3584 from Cell Signaling Technology Prices $109.00, $287.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

LAT Antibody - 9166 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

LAT (B-3) - sc-373706 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

LAT (11B.12) - sc-53550 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

LAT (F-7) - sc-514182 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

LAT (FL-233) - sc-7948 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

LAT (H-12) - sc-393364 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

LAT (M-19) - sc-5320 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LAT (Q-20) - sc-7548 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LAT (V-19) - sc-5321 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LAT (LAT-01) - sc-51663 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-LAT (phospho Y132) antibody - ab4476 from Abcam Prices $382.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-LAT (phospho Y171) antibody - ab73205 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAT (phospho Y171) antibody - ab14522 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-LAT (phospho Y191) antibody - ab59197 from Abcam Prices $379.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAT (phospho Y191) antibody [E225] - ab32434 from Abcam Prices $381.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone E225

Anti-LAT (phospho Y200) antibody [EP983(2)Y] - ab68139 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP983(2)Y

Anti-LAT antibody - ab2507 from Abcam Prices $382.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAT antibody - ab189105 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LAT antibody - ab196943 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LAT antibody - ab86751 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAT antibody - ab59229 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAT antibody - ab14518 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LAT antibody - ab57204 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

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