LAT

Gene Symbol	LAT
Entrez Gene	27040
Alt Symbol	LAT1, pp36
Species	Human
Gene Type	protein-coding
Description	linker for activation of T cells
Other Description	36 kDa phospho-tyrosine adapter protein|36 kDa phospho-tyrosine adaptor protein|linker for activation of T cells, transmembrane adaptor|linker for activation of T-cells family member 1|p36-38
Swissprots	O43919 B7WPI0 O43561 C7C5T6 G5E9K3
Accessions	EAW52024 EAW52025 EAW52026 EAW52027 EAW52028 EAW52029 EAW52030 EAW52031 O43561 AF036905 AAC39636 AF036906 AAC39637 AJ223280 CAA11218 AK093815 AK307342 BC011563 AAH11563 BI769296 BI911769 FN432831 CBA11532 FN432832 CBA11533 FN432833 CBA11534 FN432834 CBA11535 NM_001014987 NP_001014987 NM_001014988 NP_001014988 NM_001014989 NP_001014989 NM_014387 NP_055202
Function	Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts.
Tissue Specificity	Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). {ECO:0000269|PubMed:16160011, ECO:0000269|PubMed:9489702}.
Top Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-LAT (Tyr191) Sandwich ELISA Kit - 7936 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-LAT (Tyr191) Sandwich ELISA Antibody Pair - 7937 from Cell Signaling Technology Category Antibody Pair Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

Human LAT ELISA Kit (Sandwich ELISA) - LS-F4828 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.102 ng/ml Range 0.313-20 ng/ml

Human LAT ELISA Kit (Sandwich ELISA) - LS-F5413 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-LAT (Tyr171) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1254 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat LAT ELISA Kit (Cell-Based ELISA) - LS-F2116 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-LAT (Tyr191) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1184 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Human LAT ELISA Kit - abx152172 from Abbexa Category ELISA Kit Sensitivity 0.102 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human LAT ELISA Kit - abx054132 from Abbexa Category ELISA Kit

Human LAT1 ELISA Kit - abx152173 from Abbexa Category ELISA Kit Sensitivity 0.056 ng/ml Range 0.156 ng/ml - 10 ng/ml

Linker For Activation of T-cell, LAT, Human, ELISA Kit - E-EL-H0955 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Linker for activation of T cell, LAT, Human, ELISA Kit - CSB-E10077h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Linker For Activation Of T-Cell (LAT), Human, ELISA Kit - SEA270Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.102ng/mL Range 0.312-20ng/mL

Linker for activation of T-cells family member 1, LAT, Human, ELISA Kit - E0270h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Linker for activation of T cell, LAT, Mouse, ELISA Kit - E-EL-M0754 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Linker For Activation of T-cell, LAT, Rabbit, ELISA Kit - E-EL-RB1884 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Linker For Activation of T-cell, LAT, Chicken, ELISA Kit - E-EL-Ch1536 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Linker For Activation of T-cell, LAT, Porcine, ELISA Kit - E-EL-P0983 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Linker For Activation of T-cell, LAT, Sheep, ELISA Kit - E-EL-S0584 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Linker For Activation of T-cell, LAT, Guinea Pig, ELISA Kit - E-EL-GP0843 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Linker For Activation of T-cell, LAT, Monkey, ELISA Kit - E-EL-MK1687 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

LAT, ELISA Kit - MBS2506509 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

LAT, ELISA Kit - MBS2514286 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

LAT, ELISA Kit - MBS2512541 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

LAT, ELISA Kit - MBS2511007 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

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