LAT

Gene Symbol	LAT
Entrez Gene	27040
Alt Symbol	LAT1, pp36
Species	Human
Gene Type	protein-coding
Description	linker for activation of T cells
Other Description	36 kDa phospho-tyrosine adapter protein|36 kDa phospho-tyrosine adaptor protein|linker for activation of T cells, transmembrane adaptor|linker for activation of T-cells family member 1|p36-38
Swissprots	O43919 B7WPI0 O43561 C7C5T6 G5E9K3
Accessions	EAW52024 EAW52025 EAW52026 EAW52027 EAW52028 EAW52029 EAW52030 EAW52031 O43561 AF036905 AAC39636 AF036906 AAC39637 AJ223280 CAA11218 AK093815 AK307342 BC011563 AAH11563 BI769296 BI911769 FN432831 CBA11532 FN432832 CBA11533 FN432833 CBA11534 FN432834 CBA11535 NM_001014987 NP_001014987 NM_001014988 NP_001014988 NM_001014989 NP_001014989 NM_014387 NP_055202
Function	Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts.
Tissue Specificity	Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). {ECO:0000269|PubMed:16160011, ECO:0000269|PubMed:9489702}.
Top Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LAT-Over-expression-Lysate - LY13654a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

LAT overexpression lysate - LY423103 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

LAT overexpression lysate - LY425376 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

LAT 293 Cell Lysate - 409863 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

LAT 293 Cell Lysate - 402040 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

LAT Overexpression Lysate (Native) - NBP2-09156 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

LAT Over-expression Lysate Product - GWB-EFDA60 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

LAT Over-expression Lysate Product - GWB-C49D5D from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human LAT Knockdown Stable Cell Line - CSC-DC008558 from Creative biogene Category Cell Line Species Human

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