LAT
| Gene Symbol | LAT |
|---|---|
| Entrez Gene | 27040 |
| Alt Symbol | LAT1, pp36 |
| Species | Human |
| Gene Type | protein-coding |
| Description | linker for activation of T cells |
| Other Description | 36 kDa phospho-tyrosine adapter protein|36 kDa phospho-tyrosine adaptor protein|linker for activation of T cells, transmembrane adaptor|linker for activation of T-cells family member 1|p36-38 |
| Swissprots | O43919 B7WPI0 O43561 C7C5T6 G5E9K3 |
| Accessions | EAW52024 EAW52025 EAW52026 EAW52027 EAW52028 EAW52029 EAW52030 EAW52031 O43561 AF036905 AAC39636 AF036906 AAC39637 AJ223280 CAA11218 AK093815 AK307342 BC011563 AAH11563 BI769296 BI911769 FN432831 CBA11532 FN432832 CBA11533 FN432833 CBA11534 FN432834 CBA11535 NM_001014987 NP_001014987 NM_001014988 NP_001014988 NM_001014989 NP_001014989 NM_014387 NP_055202 |
| Function | Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts. |
| Tissue Specificity | Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). {ECO:0000269|PubMed:16160011, ECO:0000269|PubMed:9489702}. |
| Top Pathways | Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Rap1 signaling pathway |
LAT CRISPR/Cas9 KO Plasmid (h) - sc-401281 from Santa Cruz Biotechnology
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LAT HDR Plasmid (h) - sc-401281-HDR from Santa Cruz Biotechnology
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LAT Double Nickase Plasmid (h) - sc-401281-NIC from Santa Cruz Biotechnology
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LAT Double Nickase Plasmid (h2) - sc-401281-NIC-2 from Santa Cruz Biotechnology
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LAT CRISPR Activation Plasmid (h) - sc-401281-ACT from Santa Cruz Biotechnology
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LAT CRISPR Activation Plasmid (h2) - sc-401281-ACT-2 from Santa Cruz Biotechnology
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LAT Lentiviral Activation Particles (h) - sc-401281-LAC from Santa Cruz Biotechnology
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LAT Lentiviral Activation Particles (h2) - sc-401281-LAC-2 from Santa Cruz Biotechnology
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LAT siRNA (h) - sc-35795 from Santa Cruz Biotechnology
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LAT shRNA Plasmid (h) - sc-35795-SH from Santa Cruz Biotechnology
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LAT shRNA (h) Lentiviral Particles - sc-35795-V from Santa Cruz Biotechnology
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LAT RNAi - H00027040-R02 from Novus Biologicals
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LAT RNAi - H00027040-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN11566 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11566 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04877 from Sigma-Aldrich
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LAT siRNA (Human) - CRH8937 from Cohesion Biosciences
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LAT RNAi - H00027040-R03 from Novus Biologicals
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LAT RNAi - H00027040-R04 from Novus Biologicals
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LAT CRISPR/Cas9 KO Plasmid (h2) - sc-401281-KO-2 from Santa Cruz Biotechnology
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LAT HDR Plasmid (h2) - sc-401281-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human LAT (NM_014387.3) - SHH328655 from Creative biogene
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shRNA set against Human LAT(NM_001014987.1) - SHH143057 from Creative biogene
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shRNA set against Human LAT(NM_001014988.1) - SHH143075 from Creative biogene
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shRNA set against Human LAT(NM_014387.3) - SHH143093 from Creative biogene
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