LAT

Gene Symbol	LAT
Entrez Gene	27040
Alt Symbol	LAT1, pp36
Species	Human
Gene Type	protein-coding
Description	linker for activation of T cells
Other Description	36 kDa phospho-tyrosine adapter protein|36 kDa phospho-tyrosine adaptor protein|linker for activation of T cells, transmembrane adaptor|linker for activation of T-cells family member 1|p36-38
Swissprots	O43919 B7WPI0 O43561 C7C5T6 G5E9K3
Accessions	EAW52024 EAW52025 EAW52026 EAW52027 EAW52028 EAW52029 EAW52030 EAW52031 O43561 AF036905 AAC39636 AF036906 AAC39637 AJ223280 CAA11218 AK093815 AK307342 BC011563 AAH11563 BI769296 BI911769 FN432831 CBA11532 FN432832 CBA11533 FN432833 CBA11534 FN432834 CBA11535 NM_001014987 NP_001014987 NM_001014988 NP_001014988 NM_001014989 NP_001014989 NM_014387 NP_055202
Function	Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts.
Tissue Specificity	Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). {ECO:0000269|PubMed:16160011, ECO:0000269|PubMed:9489702}.
Top Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LAT full length protein - ab131956 from Abcam Category Protein Source Wheat germ Species Human

Human LAT peptide - ab45595 from Abcam Category Peptide Species Human

Human LAT protein fragment - ab113124 from Abcam Category Protein Source E. coli Species Human

LAT Antibody Blocking Peptide - LS-E25739 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LAT Recombinant Protein - H00027040-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human LAT Protein - NBP1-72479 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 50 µg, 250 µg Source E. coli Species Human

LAT blocking peptide - GTX17032-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Human LAT protein - orb168715 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E.coli Species Human

LAT Immunizing peptide - orb17878 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

LAT protein (His tag) - 80R-1993 from Fitzgerald Category Protein Prices $270.00 Sizes 50 µg Source E.coli

LAT (phospho-Tyr191) Blocking Peptide - abx063815 from Abbexa Category Peptide Species Human, Mouse, Rat

LAT (phospho-Tyr255) Blocking Peptide - abx064249 from Abbexa Category Peptide Species Human, Mouse, Rat

LAT Peptide - AC21-0568-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

LAT (28-233, His-tag) - AR50063PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

LAT (28-233, His-tag) - AR50063PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

LAT - H00027040-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LAT - H00027040-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Linker for Activation of T Cells, Human Recombinant - 228-13387-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Linker for Activation of T Cells - 228-13387-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source E.coli. Species Human

Recombinant Human Linker for Activation of T Cells - 228-13387-3 from RayBiotech Category Protein Source E.coli. Species Human

LAT, 28-233 aa, Human, His tag, E.coli - 01-P1238 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

LAT Peptide - 45-080P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

LAT fusion protein - ag1868 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

LAT Human - PRPS-955 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source E.coli. Species Human

Recombinant Human LAT Protein - BP002688-PRO-948 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. Coli-derived. Species Human

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