NDP

Gene Symbol	NDP
Entrez Gene	4693
Alt Symbol	EVR2, FEVR, ND
Species	Human
Gene Type	protein-coding
Description	Norrie disease (pseudoglioma)
Other Description	X-linked exudative vitreoretinopathy 2 protein|norrie disease protein|norrin
Swissprots	B2R8K6 Q00604 Q5JYH5
Accessions	EAW59376 Q00604 AK313409 BAG36203 AM392592 CAL37470 BC029901 AAH29901 BE139596 DA714180 X65724 CAA46639 X65882 CAA46713 NM_000266 NP_000257
Function	Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Subcellular Location	Secreted {ECO:0000269|PubMed:9407136}.
Tissue Specificity	Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain. {ECO:0000269|PubMed:10452356}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NDP gene - orb90854 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-NDP-cDNA-Clone - DC06035 from Abgent, a WuXi AppTec company Prices $179.55 Sizes 10 µg Species Human Accession BC029901

Human NDP ORF clone(NM_000266.3) - CDCL185443 from Creative Biomart Species Human Accession NM_000266.3

Human NDP/EVR2 Gene ORF cDNA clone in cloning vector - HG10263-M from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10263-ACR from Sino Biological Species Human

Human NDP / EVR2 Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10263-M-N from Sino Biological Species Human Accession NM_000266.3

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10263-ACG from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, N-His tag - HG10263-NH from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10263-M-F from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid - HG10263-UT from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10263-CY from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10263-NF from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10263-CF from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10263-NM from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, C-His tag - HG10263-CH from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10263-NY from Sino Biological Species Human

Human NDP/EVR2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10263-CM from Sino Biological Species Human

Human NDP ORF clone(NM_000266.3) - CDCL185443 from Creative biogene Species Human

Human NDP ORF Clone (BC029901) - CDCS405534 from Creative biogene Species Human Accession Q00604

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