NDP

Gene Symbol NDP
Entrez Gene 4693
Alt Symbol EVR2, FEVR, ND
Species Human
Gene Type protein-coding
Description Norrie disease (pseudoglioma)
Other Description X-linked exudative vitreoretinopathy 2 protein|norrie disease protein|norrin
Swissprots B2R8K6 Q00604 Q5JYH5
Accessions EAW59376 Q00604 AK313409 BAG36203 AM392592 CAL37470 BC029901 AAH29901 BE139596 DA714180 X65724 CAA46639 X65882 CAA46713 NM_000266 NP_000257
Function Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Subcellular Location Secreted {ECO:0000269|PubMed:9407136}.
Tissue Specificity Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain. {ECO:0000269|PubMed:10452356}.

NORRIN CRISPR/Cas9 KO Plasmid (h) - sc-405323 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NORRIN HDR Plasmid (h) - sc-405323-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NORRIN Double Nickase Plasmid (h) - sc-405323-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NORRIN Double Nickase Plasmid (h2) - sc-405323-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NORRIN CRISPR Activation Plasmid (h) - sc-405323-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NORRIN CRISPR Activation Plasmid (h2) - sc-405323-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NORRIN Lentiviral Activation Particles (h) - sc-405323-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NORRIN Lentiviral Activation Particles (h2) - sc-405323-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NORRIN siRNA (h) - sc-61217 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NORRIN shRNA Plasmid (h) - sc-61217-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NORRIN shRNA (h) Lentiviral Particles - sc-61217-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU057121 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15125 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15125 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07718 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07718

NDP siRNA (Human) - CRH3108 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NDP (NM_000266.3) - SHH350352 from Creative biogene

Category siRNA
Species Reactivities Human

Human NDP siRNA - orb263610 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NDP shRNA Plasmid (Human) - CHH3108 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NDP miRNA 3'UTR clone - MiUTR3H-02891 from Creative biogene

Species Reactivities Human
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