NDP

Gene Symbol	NDP
Entrez Gene	4693
Alt Symbol	EVR2, FEVR, ND
Species	Human
Gene Type	protein-coding
Description	Norrie disease (pseudoglioma)
Other Description	X-linked exudative vitreoretinopathy 2 protein|norrie disease protein|norrin
Swissprots	B2R8K6 Q00604 Q5JYH5
Accessions	EAW59376 Q00604 AK313409 BAG36203 AM392592 CAL37470 BC029901 AAH29901 BE139596 DA714180 X65724 CAA46639 X65882 CAA46713 NM_000266 NP_000257
Function	Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Subcellular Location	Secreted {ECO:0000269|PubMed:9407136}.
Tissue Specificity	Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain. {ECO:0000269|PubMed:10452356}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NDP full length protein - ab158957 from Abcam Category Protein Source Wheat germ Species Human

Human NDP full length protein - ab171607 from Abcam Category Protein Source E. coli Species Human

Human NDP protein fragment - ab158958 from Abcam Category Protein Source Wheat germ Species Human

NDP Antibody Blocking Peptide - LS-E30680 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NDP/Norrin Recombinant Protein - H00004693-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Norrin/NDP Partial Recombinant Protein - H00004693-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Norrin/NDP Protein - NBP2-23294 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Source E.coli Species Human

Norrin/NDP Blocking Peptide - NBP1-77014PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

NDP-Antibody-N-term-Blocking-Peptide - BP9110a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Norrin Peptide - GTX85292-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Recombinant Human Norrin, CF - 3014-NR-025 from R&D Systems Category Protein Source E. coli-derived, Lys25-Ser133, with an N-terminal Met

Human NDP protein - orb191302 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli Species Human

NDP Blocking Peptide - 33R-2114 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NDP protein (His tag) - 80R-2996 from Fitzgerald Category Protein Prices $275.00 Sizes 50 µg Source E.coli

NDP (25-133, His-tag) - AR51114PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

NDP (25-133, His-tag) - AR51114PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

NDP - H00004693-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NDP - H00004693-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NDP - H00004693-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NDP - H00004693-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NDP Control Peptide - AP30608CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

NDP, 25-133aa, Human, His tag, E.coli - 01-P2290 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Norrin Peptide - 5119P from ProSci Category Peptide Species Human

NDP fusion protein - ag17144 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NDP fusion protein - ag4066 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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