NUS1

Gene Symbol NUS1
Entrez Gene 116150
Alt Symbol C6orf68, MGC:7199, NgBR, TANGO14
Species Human
Gene Type protein-coding
Description nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
Other Description Nogo-B receptor|dehydrodolichyl diphosphate syntase complex subunit NUS1|di-trans,poly-cis-decaprenylcistransferase|transport and golgi organization 14 homolog
Swissprots O00251 B2RWQ4 Q96E22
Accessions EAW48201 Q96E22 AJ420576 AK025467 AK125119 BAG54148 AK126335 AK130093 BC013026 AAH13026 BC063794 AAH63794 BC066910 AAH66910 BC110325 AAI10326 BC150654 AAI50655 BC150655 AAI50656 NM_138459 NP_612468
Function With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:19723497, ECO:0000269|PubMed:21572394}; Multi- pass membrane protein {ECO:0000303|PubMed:21572394}. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. {ECO:0000269|PubMed:19723497}.
Top Pathways Terpenoid backbone biosynthesis

NgBR (P-15) - sc-138044 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NgBR (P-15): sc-138044. Western blot analysis of NgBR expression in HeLa (A) and MIA PaCa-2 (B) whole cell lysates.

NgBR (S-12) - sc-138045 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NgBR (S-12): sc-138045. Western blot analysis of NgBR expression in HeLa whole cell lysate.

Anti-Nogo B receptor antibody - ab47080 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Nogo B receptor antibody (ab47080) at 2 µg/mlLane 1 : Human brain tissue lysateLane 2 : Mouse brain tissue lysateLane 3 : Rat brain tissue lysate

Anti-Nogo B receptor antibody [EPR8668] - ab168351 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8668
All lanes : Anti-Nogo B receptor antibody [EPR8668] (ab168351) at 1/1000 dilutionLane 1 : A549 cell lysateLane 2 : HUVEC cell lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit at 1/2000 dilution

Anti-NUS1 Antibody (aa84-97) - LS-C143971 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-NUS1 Antibody (aa64-74) - LS-C143972 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NUS1 Antibody (aa84-97) - LS-C148064 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-NUS1 Antibody (aa38-116, clone 6C11) - LS-C338658 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6C11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NUS1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NUS1.

Anti-NUS1 Antibody (aa151-200) - LS-C170435 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Nogo B receptor Antibody - NBP2-24950 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Nogo B receptor Antibody [NBP2-24950] - Western blot analysis of Nogo-Breceptor in A) human, B) mouse and C) rat brain tissue lysate using NBP2-24950 at 2ug/ml.

Nogo B receptor Antibody - NBP1-88252 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody - bs-11468R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11468R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11468R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11468R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11468R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, Cy3 Conjugated - bs-11468R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, Cy5 Conjugated - bs-11468R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, Cy5.5 Conjugated - bs-11468R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, Cy7 Conjugated - bs-11468R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, FITC Conjugated - bs-11468R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, Biotin Conjugated - bs-11468R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NGBR/Nogo B receptor Polyclonal Antibody, HRP Conjugated - bs-11468R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NUS1 antibody produced in rabbit - HPA027504 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NUS1: <B>Cat. No. HPA027504</B>: Immunohistochemical staining of human rectum shows distinct positivity in blood vessels and adipocytes.

Anti-NUS1 (166-180) antibody produced in rabbit - SAB1103237 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human NUS1 was separated on SDS-PAGE, blotted with Anti-NUS1 (166-180) (<B>Cat. No. SAB1103237</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:250
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