| Gene Symbol | NUS1 |
|---|---|
| Entrez Gene | 116150 |
| Alt Symbol | C6orf68, MGC:7199, NgBR, TANGO14 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) |
| Other Description | Nogo-B receptor|dehydrodolichyl diphosphate syntase complex subunit NUS1|di-trans,poly-cis-decaprenylcistransferase|transport and golgi organization 14 homolog |
| Swissprots | O00251 B2RWQ4 Q96E22 |
| Accessions | EAW48201 Q96E22 AJ420576 AK025467 AK125119 BAG54148 AK126335 AK130093 BC013026 AAH13026 BC063794 AAH63794 BC066910 AAH66910 BC110325 AAI10326 BC150654 AAI50655 BC150655 AAI50656 NM_138459 NP_612468 |
| Function | With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:19723497, ECO:0000269|PubMed:21572394}; Multi- pass membrane protein {ECO:0000303|PubMed:21572394}. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. {ECO:0000269|PubMed:19723497}. |
| Top Pathways | Terpenoid backbone biosynthesis |