| Gene Symbol |
NUS1
|
| Entrez Gene |
116150
|
| Alt Symbol |
C6orf68, MGC:7199, NgBR, TANGO14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
|
| Other Description |
Nogo-B receptor|dehydrodolichyl diphosphate syntase complex subunit NUS1|di-trans,poly-cis-decaprenylcistransferase|transport and golgi organization 14 homolog
|
| Swissprots |
O00251 B2RWQ4 Q96E22
|
| Accessions |
EAW48201 Q96E22 AJ420576 AK025467 AK125119 BAG54148 AK126335 AK130093 BC013026 AAH13026 BC063794 AAH63794 BC066910 AAH66910 BC110325 AAI10326 BC150654 AAI50655 BC150655 AAI50656 NM_138459 NP_612468
|
| Function |
With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:19723497, ECO:0000269|PubMed:21572394}; Multi- pass membrane protein {ECO:0000303|PubMed:21572394}. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. {ECO:0000269|PubMed:19723497}.
|
| Top Pathways |
Terpenoid backbone biosynthesis
|