NUS1

Gene Symbol NUS1
Entrez Gene 116150
Alt Symbol C6orf68, MGC:7199, NgBR, TANGO14
Species Human
Gene Type protein-coding
Description nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
Other Description Nogo-B receptor|dehydrodolichyl diphosphate syntase complex subunit NUS1|di-trans,poly-cis-decaprenylcistransferase|transport and golgi organization 14 homolog
Swissprots O00251 B2RWQ4 Q96E22
Accessions EAW48201 Q96E22 AJ420576 AK025467 AK125119 BAG54148 AK126335 AK130093 BC013026 AAH13026 BC063794 AAH63794 BC066910 AAH66910 BC110325 AAI10326 BC150654 AAI50655 BC150655 AAI50656 NM_138459 NP_612468
Function With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:19723497, ECO:0000269|PubMed:21572394}; Multi- pass membrane protein {ECO:0000303|PubMed:21572394}. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. {ECO:0000269|PubMed:19723497}.
Top Pathways Terpenoid backbone biosynthesis

Human Nogo B receptor full length protein - ab165100 from Abcam

Category Protein
Source Wheat germ
Species Human
ab165100 on a 12.5% SDS-PAGE stained with Coomassie Blue.

NUS1 Antibody Blocking Peptide - LS-E24253 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Nogo B receptor Protein - H00116150-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

Nogo-B receptor - H00116150-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

NUS1 fusion protein - Ag8959 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

NUS1 fusion protein - Ag8789 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human NUS1, His-tagged - NUS1-1424H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Nogo-B receptor(NUS1) - CSB-YP842661HU CSB-EP842661HU CSB-BP842661HU CSB-MP842661HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Nogo B receptor Recombinant Protein Antigen - NBP1-88252PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

NUS1 Peptide, Human - M34GP10754H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Nogo-B receptor (NUS1), Recombinant Protein - MBS1372112 from MyBioSource

Category Protein
Prices $825.00, $825.00, $1,050.00, $1,050.00, $1,175.00, $1,175.00, $1,630.00, $1,630.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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