NUS1

Gene Symbol NUS1
Entrez Gene 116150
Alt Symbol C6orf68, MGC:7199, NgBR, TANGO14
Species Human
Gene Type protein-coding
Description nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
Other Description Nogo-B receptor|dehydrodolichyl diphosphate syntase complex subunit NUS1|di-trans,poly-cis-decaprenylcistransferase|transport and golgi organization 14 homolog
Swissprots O00251 B2RWQ4 Q96E22
Accessions EAW48201 Q96E22 AJ420576 AK025467 AK125119 BAG54148 AK126335 AK130093 BC013026 AAH13026 BC063794 AAH63794 BC066910 AAH66910 BC110325 AAI10326 BC150654 AAI50655 BC150655 AAI50656 NM_138459 NP_612468
Function With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:19723497, ECO:0000269|PubMed:21572394}; Multi- pass membrane protein {ECO:0000303|PubMed:21572394}. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. {ECO:0000269|PubMed:19723497}.
Top Pathways Terpenoid backbone biosynthesis

NgBR CRISPR/Cas9 KO Plasmid (h) - sc-417934 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NgBR HDR Plasmid (h) - sc-417934-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NgBR Double Nickase Plasmid (h) - sc-417934-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NgBR Double Nickase Plasmid (h2) - sc-417934-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NgBR CRISPR Activation Plasmid (h) - sc-417934-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NgBR CRISPR Activation Plasmid (h2) - sc-417934-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NgBR Lentiviral Activation Particles (h) - sc-417934-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NgBR Lentiviral Activation Particles (h2) - sc-417934-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NgBR siRNA (h) - sc-95494 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NgBR shRNA Plasmid (h) - sc-95494-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NgBR shRNA (h) Lentiviral Particles - sc-95494-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU111481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15641 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15641 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NUS1 siRNA (Human) - CRJ4491 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NUS1 (NM_138459.3) - SHH356624 from Creative biogene

Category siRNA
Species Reactivities Human

NUS1 shRNA Plasmid (Human) - CHJ4491 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NUS1 miRNA 3'UTR clone - MiUTR1H-07002 from Creative biogene

Species Reactivities Human
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