| Gene Symbol |
HSH2D
|
| Entrez Gene |
84941
|
| Alt Symbol |
ALX, HSH2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hematopoietic SH2 domain containing
|
| Other Description |
adaptor in lymphocytes of unknown function X|hematopoietic SH2 domain-containing protein
|
| Swissprots |
Q6ZNG7 B5ME72 Q96JZ2
|
| Accessions |
EAW84528 EAW84529 EAW84530 EAW84531 EAW84532 Q96JZ2 AK027792 BAB55372 AK131222 BAD18408 AK298682 BAG60845 AK300027 BAG61838 AK307563 AY319652 AAQ81285 BC016826 AAH16826 BC025237 AAH25237 BF511682 DQ892165 ABM83091 DQ895359 ABM86285 XM_011528386 XP_011526688 XM_011528387 XP_011526689 XM_011528388 XP_011526690 XM_011528389 XP_011526691 XM_011528390 XP_011526692 NM_001291274 NP_001278203 NM_032855 NP_116244 NR_111903 NR_111904
|
| Function |
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta. {ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172}.
|