Gene Symbol | HSH2D |
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Entrez Gene | 84941 |
Alt Symbol | ALX, HSH2 |
Species | Human |
Gene Type | protein-coding |
Description | hematopoietic SH2 domain containing |
Other Description | adaptor in lymphocytes of unknown function X|hematopoietic SH2 domain-containing protein |
Swissprots | Q6ZNG7 B5ME72 Q96JZ2 |
Accessions | EAW84528 EAW84529 EAW84530 EAW84531 EAW84532 Q96JZ2 AK027792 BAB55372 AK131222 BAD18408 AK298682 BAG60845 AK300027 BAG61838 AK307563 AY319652 AAQ81285 BC016826 AAH16826 BC025237 AAH25237 BF511682 DQ892165 ABM83091 DQ895359 ABM86285 XM_011528386 XP_011526688 XM_011528387 XP_011526689 XM_011528388 XP_011526690 XM_011528389 XP_011526691 XM_011528390 XP_011526692 NM_001291274 NP_001278203 NM_032855 NP_116244 NR_111903 NR_111904 |
Function | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
Subcellular Location | Cytoplasm. Nucleus. |
Tissue Specificity | Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta. {ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172}. |
Human HSH2D full length protein - ab164703 from Abcam
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Human HSH2D protein fragment - ab164704 from Abcam
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ALX / HSH2D Antibody Blocking Peptide - LS-E22208 from LifeSpan Bioscience
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ALX / HSH2D Antibody Blocking Peptide - LS-E22209 from LifeSpan Bioscience
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ALX / HSH2D Antibody Blocking Peptide - LS-E27312 from LifeSpan Bioscience
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ALX / HSH2D Antibody Blocking Peptide - LS-E27311 from LifeSpan Bioscience
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Recombinant Human HSH2D Protein - H00084941-Q01 from Novus Biologicals
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Recombinant Human HSH2D Protein - H00084941-P01 from Novus Biologicals
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HSH2D (aa325-339) blocking peptide - GTX88193-PEP from GeneTex
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HSH2D blocking peptide - GTX88192-PEP from GeneTex
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HSH2D Blocking Peptide - 33R-2096 from Fitzgerald
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HSH2D Peptide - AC21-2134-P from Abcore
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HSH2D Peptide - AC21-2135-P from Abcore
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HSH2D / ALX - H00084941-P01-10 from Acris Antibodies
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HSH2D / ALX - H00084941-P01-25 from Acris Antibodies
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HSH2D / ALX - H00084941-Q01-10 from Acris Antibodies
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HSH2D / ALX - H00084941-Q01-25 from Acris Antibodies
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HSH2D Peptide - 42-539P from ProSci
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HSH2D Peptide - 42-538P from ProSci
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HSH2D fusion protein - ag2363 from Proteintech Group
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Recombinant Human Hematopoietic SH2 domain-containing protein(HSH2D) - CSB-YP850321HU CSB-EP850321HU CSB-BP850321HU CSB-MP850321HU from Cusabio
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HSH2D / ALX - TP306816 from Acris Antibodies
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HSH2D, Peptide - MBS428433 from MyBioSource
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HSH2D, Peptide - MBS427229 from MyBioSource
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HSH2D Protein - NBP1-89109PEP from Novus Biologicals
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