| Gene Symbol |
NANOS3
|
| Entrez Gene |
342977
|
| Alt Symbol |
NANOS1L, NOS3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nanos homolog 3 (Drosophila)
|
| Other Description |
nanos homolog 3
|
| Swissprots |
Q495E5 P60323
|
| Accessions |
P60323 BC101209 AAI01210 BC101210 AAI01211 BI793167 CK821051 CK821052 DN993610 XM_011527964 XP_011526266 NM_001098622 NP_001092092
|
| Function |
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269|PubMed:21421998}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Cytoplasmic granule {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Colocalizes with DCP1A in the P-body (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids. {ECO:0000269|PubMed:21421998}.
|