NANOS3

Gene Symbol NANOS3
Entrez Gene 342977
Alt Symbol NANOS1L, NOS3
Species Human
Gene Type protein-coding
Description nanos homolog 3 (Drosophila)
Other Description nanos homolog 3
Swissprots Q495E5 P60323
Accessions P60323 BC101209 AAI01210 BC101210 AAI01211 BI793167 CK821051 CK821052 DN993610 XM_011527964 XP_011526266 NM_001098622 NP_001092092
Function Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269|PubMed:21421998}.
Subcellular Location Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Cytoplasmic granule {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Colocalizes with DCP1A in the P-body (By similarity). {ECO:0000250}.
Tissue Specificity Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids. {ECO:0000269|PubMed:21421998}.

Nanos3 CRISPR/Cas9 KO Plasmid (h) - sc-407364 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nanos3 HDR Plasmid (h) - sc-407364-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nanos3 Double Nickase Plasmid (h) - sc-407364-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nanos3 Double Nickase Plasmid (h2) - sc-407364-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nanos3 CRISPR Activation Plasmid (h) - sc-407364-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nanos3 CRISPR Activation Plasmid (h2) - sc-407364-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nanos3 Lentiviral Activation Particles (h) - sc-407364-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nanos3 Lentiviral Activation Particles (h2) - sc-407364-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nanos3 siRNA (h) - sc-75868 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nanos3 shRNA Plasmid (h) - sc-75868-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nanos3 shRNA (h) Lentiviral Particles - sc-75868-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eNOS RNAi - H00004846-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU057021 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14942 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14942 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NANOS3 siRNA (Human) - CRJ7417 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NANOS3 (NM_001098622.2) - SHH349193 from Creative biogene

Category siRNA
Species Reactivities Human

NANOS3 shRNA Plasmid (Human) - CHJ7417 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NANOS3 miRNA 3'UTR clone - MiUTR3H-09856 from Creative biogene

Species Reactivities Human
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