| Gene Symbol |
TINF2
|
| Entrez Gene |
26277
|
| Alt Symbol |
DKCA3, TIN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TERF1 (TRF1)-interacting nuclear factor 2
|
| Other Description |
TERF1-interacting nuclear factor 2|TRF1-interacting nuclear protein 2
|
| Swissprots |
Q9UHC2 Q9H904 Q9BSI4 B3W5Q7
|
| Accessions |
EAW66048 EAW66049 EAW66050 Q9BSI4 AF195512 AAF18439 AK023166 BAB14440 AK225379 AK294119 BAG57452 AK315084 BC005030 AAH05030 BC019343 AAH19343 BM549897 BX161478 CAD61933 DA053760 DQ893390 ABM84316 DQ896711 ABM87710 EU851975 ACF17559 XM_005267528 XP_005267585 XM_005267529 XP_005267586 XM_011536642 XP_011534944 NM_001099274 NP_001092744 NM_012461 NP_036593
|
| Function |
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19279399}. Chromosome, telomere {ECO:0000269|PubMed:19279399}. Note=Associated with telomeres.
|
| Tissue Specificity |
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
|
![Western Blot: TIN2 Overexpression Lysate (Adult Normal) [NBL1-16930] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TIN2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4336_TIN2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16930-img0002.jpg)