| Gene Symbol |
PLEKHF2
|
| Entrez Gene |
79666
|
| Alt Symbol |
EAPF, PHAFIN2, ZFYVE18
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology domain containing, family F (with FYVE domain) member 2
|
| Other Description |
PH and FYVE domain-containing protein 2|PH domain-containing family F member 2|endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains|pleckstrin homology domain-containing family F member 2|zinc finger FYVE domain-containing protein 18
|
| Swissprots |
Q9H8W4
|
| Accessions |
EAW91743 Q9H8W4 AA767886 AF434819 AAL30774 AK023249 BAB14486 AL834473 CAD39132 AM392581 CAL37459 AM393625 CAL38501 BC011806 AAH11806 DQ893409 ABM84335 DQ896728 ABM87727 NM_024613 NP_078889
|
| Function |
May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}.
|
| Subcellular Location |
Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots. May translocate to the endoplasmic reticulum in the early phase of apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467}.
|
| Tissue Specificity |
Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells. {ECO:0000269|PubMed:18288467}.
|