PLEKHF2

Gene Symbol PLEKHF2
Entrez Gene 79666
Alt Symbol EAPF, PHAFIN2, ZFYVE18
Species Human
Gene Type protein-coding
Description pleckstrin homology domain containing, family F (with FYVE domain) member 2
Other Description PH and FYVE domain-containing protein 2|PH domain-containing family F member 2|endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains|pleckstrin homology domain-containing family F member 2|zinc finger FYVE domain-containing protein 18
Swissprots Q9H8W4
Accessions EAW91743 Q9H8W4 AA767886 AF434819 AAL30774 AK023249 BAB14486 AL834473 CAD39132 AM392581 CAL37459 AM393625 CAL38501 BC011806 AAH11806 DQ893409 ABM84335 DQ896728 ABM87727 NM_024613 NP_078889
Function May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}.
Subcellular Location Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots. May translocate to the endoplasmic reticulum in the early phase of apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467}.
Tissue Specificity Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells. {ECO:0000269|PubMed:18288467}.

Human-PLEKHF2-cDNA-Clone - DC03202 from Abgent, a WuXi AppTec company

Prices $336.15
Sizes 10 µg
Species Human
Accession BC011806

PLEKHF2 - MBS1275861 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC011806

Human PLEKHF2 ORF Clone (BC011806) - CDCS415763 from Creative biogene

Species Human
Accession Q9H8W4
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