PLEKHF2

Gene Symbol PLEKHF2
Entrez Gene 79666
Alt Symbol EAPF, PHAFIN2, ZFYVE18
Species Human
Gene Type protein-coding
Description pleckstrin homology domain containing, family F (with FYVE domain) member 2
Other Description PH and FYVE domain-containing protein 2|PH domain-containing family F member 2|endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains|pleckstrin homology domain-containing family F member 2|zinc finger FYVE domain-containing protein 18
Swissprots Q9H8W4
Accessions EAW91743 Q9H8W4 AA767886 AF434819 AAL30774 AK023249 BAB14486 AL834473 CAD39132 AM392581 CAL37459 AM393625 CAL38501 BC011806 AAH11806 DQ893409 ABM84335 DQ896728 ABM87727 NM_024613 NP_078889
Function May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}.
Subcellular Location Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots. May translocate to the endoplasmic reticulum in the early phase of apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467}.
Tissue Specificity Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells. {ECO:0000269|PubMed:18288467}.

PLEKHF2 CRISPR/Cas9 KO Plasmid (h) - sc-410618 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF2 HDR Plasmid (h) - sc-410618-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF2 Double Nickase Plasmid (h) - sc-410618-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF2 Double Nickase Plasmid (h2) - sc-410618-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF2 CRISPR Activation Plasmid (h) - sc-410618-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF2 CRISPR Activation Plasmid (h2) - sc-410618-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF2 Lentiviral Activation Particles (h) - sc-410618-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF2 Lentiviral Activation Particles (h2) - sc-410618-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF2 siRNA (h) - sc-77773 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHF2 shRNA Plasmid (h) - sc-77773-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHF2 shRNA (h) Lentiviral Particles - sc-77773-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHF2 RNAi - H00079666-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU032311 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16958 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16958 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10512 from Sigma-Aldrich

Category miRNA

PLEKHF2 siRNA (Human) - CRJ2470 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PLEKHF2 (NM_024613.3) - SHH377592 from Creative biogene

Category siRNA
Species Reactivities Human

PLEKHF2 shRNA Plasmid (Human) - CHJ2470 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PLEKHF2 miRNA 3'UTR clone - MiUTR3H-15735 from Creative biogene

Species Reactivities Human
Search more