| Gene Symbol |
NKD2
|
| Entrez Gene |
85409
|
| Alt Symbol |
Naked2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
naked cuticle homolog 2 (Drosophila)
|
| Other Description |
Dvl-binding protein NKD2|protein naked cuticle homolog 2
|
| Swissprots |
Q9BSN0 Q96EK8 Q969F2
|
| Accessions |
EAX08182 EAX08183 EAX08184 Q969F2 AB062887 BAB70501 AF358137 AAK57486 BC004940 AAH04940 BC012176 AAH12176 BE061409 XM_005248382 XP_005248439 XM_005248383 XP_005248440 XM_006725007 XP_006725070 XM_006725009 XP_006725072 XM_011514150 XP_011512452 XM_011546475 XP_011544777 NM_001271082 NP_001258011 NM_033120 NP_149111
|
| Function |
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}.
|
| Subcellular Location |
Cell membrane. Cytoplasm. Cytoplasmic vesicle.
|
| Tissue Specificity |
Expressed in kidney, lung, pancreas and spleen. {ECO:0000269|PubMed:11604995}.
|
| Top Pathways |
Wnt signaling pathway
|