Gene Symbol | NKD2 |
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Entrez Gene | 85409 |
Alt Symbol | Naked2 |
Species | Human |
Gene Type | protein-coding |
Description | naked cuticle homolog 2 (Drosophila) |
Other Description | Dvl-binding protein NKD2|protein naked cuticle homolog 2 |
Swissprots | Q9BSN0 Q96EK8 Q969F2 |
Accessions | EAX08182 EAX08183 EAX08184 Q969F2 AB062887 BAB70501 AF358137 AAK57486 BC004940 AAH04940 BC012176 AAH12176 BE061409 XM_005248382 XP_005248439 XM_005248383 XP_005248440 XM_006725007 XP_006725070 XM_006725009 XP_006725072 XM_011514150 XP_011512452 XM_011546475 XP_011544777 NM_001271082 NP_001258011 NM_033120 NP_149111 |
Function | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. |
Subcellular Location | Cell membrane. Cytoplasm. Cytoplasmic vesicle. |
Tissue Specificity | Expressed in kidney, lung, pancreas and spleen. {ECO:0000269|PubMed:11604995}. |
Top Pathways | Wnt signaling pathway |
NKD2 CRISPR/Cas9 KO Plasmid (h) - sc-407988 from Santa Cruz Biotechnology
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NKD2 HDR Plasmid (h) - sc-407988-HDR from Santa Cruz Biotechnology
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NKD2 Double Nickase Plasmid (h) - sc-407988-NIC from Santa Cruz Biotechnology
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NKD2 Double Nickase Plasmid (h2) - sc-407988-NIC-2 from Santa Cruz Biotechnology
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NKD2 CRISPR Activation Plasmid (h) - sc-407988-ACT from Santa Cruz Biotechnology
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NKD2 CRISPR Activation Plasmid (h2) - sc-407988-ACT-2 from Santa Cruz Biotechnology
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NKD2 Lentiviral Activation Particles (h) - sc-407988-LAC from Santa Cruz Biotechnology
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NKD2 Lentiviral Activation Particles (h2) - sc-407988-LAC-2 from Santa Cruz Biotechnology
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NKD2 siRNA (h) - sc-91818 from Santa Cruz Biotechnology
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NKD2 shRNA Plasmid (h) - sc-91818-SH from Santa Cruz Biotechnology
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NKD2 shRNA (h) Lentiviral Particles - sc-91818-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU160461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15321 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03475 from Sigma-Aldrich
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NKD2 siRNA (Human) - CRJ3800 from Cohesion Biosciences
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NKD2 RNAi - H00085409-R01 from Novus Biologicals
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Human NKD2 siRNA - orb274301 from Biorbyt
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NKD2 shRNA Plasmid (Human) - CHJ3800 from Cohesion Biosciences
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NKD2 miRNA 3'UTR clone - MiUTR3H-09508 from Creative biogene
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