| Gene Symbol |
NCS1
|
| Entrez Gene |
23413
|
| Alt Symbol |
FLUP, FREQ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuronal calcium sensor 1
|
| Other Description |
frequenin homolog|frequenin-like protein|frequenin-like ubiquitous protein
|
| Swissprots |
Q9UK26 E9PAY3 P62166 P36610
|
| Accessions |
EAW87926 EAW87927 P62166 AF134479 AAP97256 AF186409 AAF01804 AI521726 AI564128 AI768193 AK023889 AK024709 AL161981 BC004856 AAH04856 BC008698 BM011362 BQ880305 BU150740 CF453730 CK301145 DA092531 X84048 CAA58867 NM_001128826 NP_001122298 NM_014286 NP_055101
|
| Function |
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
|
