Gene Symbol | NCS1 |
---|---|
Entrez Gene | 23413 |
Alt Symbol | FLUP, FREQ |
Species | Human |
Gene Type | protein-coding |
Description | neuronal calcium sensor 1 |
Other Description | frequenin homolog|frequenin-like protein|frequenin-like ubiquitous protein |
Swissprots | Q9UK26 E9PAY3 P62166 P36610 |
Accessions | EAW87926 EAW87927 P62166 AF134479 AAP97256 AF186409 AAF01804 AI521726 AI564128 AI768193 AK023889 AK024709 AL161981 BC004856 AAH04856 BC008698 BM011362 BQ880305 BU150740 CF453730 CK301145 DA092531 X84048 CAA58867 NM_001128826 NP_001122298 NM_014286 NP_055101 |
Function | Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity). {ECO:0000250}. |
Subcellular Location | Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. |