| Gene Symbol |
LRIG1
|
| Entrez Gene |
26018
|
| Alt Symbol |
LIG-1, LIG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine-rich repeats and immunoglobulin-like domains 1
|
| Other Description |
leucine-rich repeat protein LRIG1|leucine-rich repeats and immunoglobulin-like domains protein 1|ortholog of mouse integral membrane glycoprotein LIG-1
|
| Swissprots |
Q9BYB8 Q96JA1 Q6IQ51 Q9UFI4 Q96CF9
|
| Accessions |
EAW65452 EAW65453 Q96JA1 AB050468 BAB40659 AF381545 AAK62357 AK126745 BAG54369 AK294984 BAH11940 AK314103 AL117666 CAB56036 AY730707 AAU44786 BC014276 AAH14276 BC071561 AAH71561 BC140907 AAI40908 XM_011533578 XP_011531880 XM_011533579 XP_011531881 NM_015541 NP_056356
|
| Function |
Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:11414704}; Single-pass type I membrane protein {ECO:0000269|PubMed:11414704}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11414704}.
|