Gene Symbol | LRIG1 |
---|---|
Entrez Gene | 26018 |
Alt Symbol | LIG-1, LIG1 |
Species | Human |
Gene Type | protein-coding |
Description | leucine-rich repeats and immunoglobulin-like domains 1 |
Other Description | leucine-rich repeat protein LRIG1|leucine-rich repeats and immunoglobulin-like domains protein 1|ortholog of mouse integral membrane glycoprotein LIG-1 |
Swissprots | Q9BYB8 Q96JA1 Q6IQ51 Q9UFI4 Q96CF9 |
Accessions | EAW65452 EAW65453 Q96JA1 AB050468 BAB40659 AF381545 AAK62357 AK126745 BAG54369 AK294984 BAH11940 AK314103 AL117666 CAB56036 AY730707 AAU44786 BC014276 AAH14276 BC071561 AAH71561 BC140907 AAI40908 XM_011533578 XP_011531880 XM_011533579 XP_011531881 NM_015541 NP_056356 |
Function | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11414704}; Single-pass type I membrane protein {ECO:0000269|PubMed:11414704}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11414704}. |