LRIG1

Gene Symbol LRIG1
Entrez Gene 26018
Alt Symbol LIG-1, LIG1
Species Human
Gene Type protein-coding
Description leucine-rich repeats and immunoglobulin-like domains 1
Other Description leucine-rich repeat protein LRIG1|leucine-rich repeats and immunoglobulin-like domains protein 1|ortholog of mouse integral membrane glycoprotein LIG-1
Swissprots Q9BYB8 Q96JA1 Q6IQ51 Q9UFI4 Q96CF9
Accessions EAW65452 EAW65453 Q96JA1 AB050468 BAB40659 AF381545 AAK62357 AK126745 BAG54369 AK294984 BAH11940 AK314103 AL117666 CAB56036 AY730707 AAU44786 BC014276 AAH14276 BC071561 AAH71561 BC140907 AAI40908 XM_011533578 XP_011531880 XM_011533579 XP_011531881 NM_015541 NP_056356
Function Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}.
Subcellular Location Membrane {ECO:0000269|PubMed:11414704}; Single-pass type I membrane protein {ECO:0000269|PubMed:11414704}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11414704}.

LRIG1 Antibody - 12752 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from U118, SNB75, and U87 cells using LRIG1 Antibody.

LRIG1 (H-108) - sc-134435 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

LRIG1 (P-16) - sc-50076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRIG1 (P-16): sc-50076. Western blot analysis of LRIG1 expression in Hep G2 (A) and Jurkat (B) whole cell lysates.

Anti-LRIG1 antibody - ab36707 from Abcam

Prices $387.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab36707 at 1/200 staining human anal cancer tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step was performed in citrate buffer. The tissue was blocked with serum and then incubated with the antibody for 45 minutes at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.See Abreview

Anti-LRIG1 antibody - ab197985 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling LRIG1 with ab197985 at 1/120 dilution.

Anti-LRIG1 antibody - ab58853 from Abcam

Prices $370.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-LRIG1 antibody - N-terminal - ab157136 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LRIG1 antibody - N-terminal (ab157136) at 1/1000 dilution + Mouse brain total cell extract

Anti-LRIG1 Antibody (aa801-829) - LS-C322713 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LRIG1 Antibody (aa801-829) - LS-C157871 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
LRIG1 Antibody western blot of mouse stomach tissue lysates (35 ug/lane). The LRIG1 antibody detected the LRIG1 protein (arrow).

LRIG1 Antibody (789211) - MAB7498 from Novus Biologicals

Prices $99.00, $259.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 789211
LRIG1 was detected in immersion fixed paraffin-embedded sections of human kidney using Mouse Anti-Human LRIG1 Monoclonal Antibody (Catalog # MAB7498) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counter­stained with hematoxylin (blue). Specific staining was localized to cytoplasm of epithelial cells in convoluted tubules. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

LRIG1 Antibody - AF7498 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
Flow Cytometry LRIG1 Antibody

LIG1 Antibody - NBP2-32603 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: LIG1 Antibody [NBP2-32603] - Staining of human duodenum shows distinct nuclear positivity in glandular cells.

LIG1 Antibody - NBP2-30926 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LIG1 Antibody [NBP2-30926] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10Lane 2: Human Cerebral Cortex tissue

LRIG1 Antibody (789211) [Allophycocyanin] - FAB7498A from Novus Biologicals

Prices $339.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 789211
LNCaP human prostate cancer cell line was stained with Mouse Anti-Human LRIG1 APC-conjugated Monoclonal Antibody (Catalog # FAB7498A, filled histogram) or isotype control antibody (Catalog # IC002N, open histogram). View our protocol for Staining Membrane-associated Proteins.

LRIG1 Antibody [Alexa Fluor 488] - FAB8140G from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Sheep
Clonality Polyclonal
LNCaP human prostate cancer cell line was stained with Sheep Anti-Human LRIG1 Alexa Fluor® 488-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB8140G, filled histogram) or isotype control antibody (Catalog # IC016G, open histogram). View our protocol for Staining Membrane-associated Proteins.

LRIG1 Polyclonal Antibody - bs-1844R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-LRIG1 Polyclonal Antibody, Unconjugated (bs-1844R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Anti-LRIG1 antibody produced in rabbit - HPA011846 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LRIG1: <B>Cat. No. HPA011846</B>: Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells, cells in molecular layer and cells in granular layer.

Monoclonal Anti-LRIG1 antibody produced in mouse - SAB4200445 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone LRIG1-21
<B>Immunofluorescence</B><BR/>LnCAP cells were fixed and permeabilized with cold methanol followed by acetone. Fixed cells were stained with 2 μg/mL Mouse Anti-LRIG1 Clone: LRIG1-21 (<B>Cat. No. SAB4200445</B>). The antibody was developed using Goat Anti-Mouse IgG, Cy3<SUP>™</SUP> conjugate. Cells were counterstained with DAPI (blue) to stain nuclei.

LRIG1-Antibody-C-term - AP19769b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
LRIG1 Antibody (C-term) (Cat. #AP19769b) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the LRIG1 antibody detected the LRIG1 protein (arrow).

LRIG1 antibody - GTX37385 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-LRIG1 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX37385

LRIG1 antibody [C2C3], C-term - GTX119485 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal

Mouse LRIG1 Antibody - AF3688 from R&D Systems

Prices $99.00, $365.00
Sizes 25 µg, 100 µg
Host Goat
Detection of Mouse LRIG1 by Western Blot. Western blot shows lysates of bEnd.3 mouse endothelioma cell line untreated (-), treated (+) or mock treated (m) with 30 pmol mouse LRIG1 or mouse ERK1 siRNA. PVDF membrane was probed with 2 µg/mL of Goat Anti-Mouse LRIG1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3688) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109 ). Specific bands were detected for LRIG1 at approximately 140 kDa and 70 kDa (as indicated, upper panel). For additional reference ERK1 was detected using Rabbit Anti-Human/Mouse/Rat ERK1 Antigen Affinity-purified Polyclonal Antibody (lower panel, Catalog # AF1575 ) This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 .

Mouse LRIG1 Affinity Purified Polyclonal Ab, Goat IgG - AF3688-SP from R&D Systems

Host Goat
Clonality Polyclonal
Detection of Mouse LRIG1 by Western Blot. Western blot shows lysates of bEnd.3 mouse endothelioma cell line untreated (-), treated (+) or mock treated (m) with 30 pmol mouse LRIG1 or mouse ERK1 siRNA. PVDF membrane was probed with 2 µg/mL of Goat Anti-Mouse LRIG1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3688) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109).  Specific bands were detected for LRIG1 at approximately 140 kDa and 70 kDa (as indicated, upper panel). For additional reference ERK1 was detected using Rabbit Anti-Human/Mouse/Rat ERK1 Antigen Affinity-purified Polyclonal Antibody (lower panel, Catalog # AF1575) This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Human LRIG1 Antibody - AF7498 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Detection of LRIG1 in LNCaP Human Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Sheep Anti-Human LRIG1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7498, filled histogram) or control antibody (Catalog # 5-001-A , open histogram), followed by Allophycocyanin-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # F0127 ).

Human LRIG1 Affinity Purified Polyclonal Ab, Sheep IgG - AF7498-SP from R&D Systems

Host Sheep
Clonality Polyclonal
Detection of LRIG1 in LNCaP Human Cell Line by Flow Cytometry. LNCaP human prostate cancer cell line was stained with Sheep Anti-Human LRIG1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7498, filled histogram) or control antibody (Catalog # 5‑001‑A, open histogram), followed by Allophycocyanin-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # F0127).
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