Gene Symbol | LRIG1 |
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Entrez Gene | 26018 |
Alt Symbol | LIG-1, LIG1 |
Species | Human |
Gene Type | protein-coding |
Description | leucine-rich repeats and immunoglobulin-like domains 1 |
Other Description | leucine-rich repeat protein LRIG1|leucine-rich repeats and immunoglobulin-like domains protein 1|ortholog of mouse integral membrane glycoprotein LIG-1 |
Swissprots | Q9BYB8 Q96JA1 Q6IQ51 Q9UFI4 Q96CF9 |
Accessions | EAW65452 EAW65453 Q96JA1 AB050468 BAB40659 AF381545 AAK62357 AK126745 BAG54369 AK294984 BAH11940 AK314103 AL117666 CAB56036 AY730707 AAU44786 BC014276 AAH14276 BC071561 AAH71561 BC140907 AAI40908 XM_011533578 XP_011531880 XM_011533579 XP_011531881 NM_015541 NP_056356 |
Function | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11414704}; Single-pass type I membrane protein {ECO:0000269|PubMed:11414704}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11414704}. |
LRIG1 CRISPR/Cas9 KO Plasmid (h) - sc-403210 from Santa Cruz Biotechnology
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LRIG1 HDR Plasmid (h) - sc-403210-HDR from Santa Cruz Biotechnology
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LRIG1 Double Nickase Plasmid (h) - sc-403210-NIC from Santa Cruz Biotechnology
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LRIG1 Double Nickase Plasmid (h2) - sc-403210-NIC-2 from Santa Cruz Biotechnology
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LRIG1 CRISPR Activation Plasmid (h) - sc-403210-ACT from Santa Cruz Biotechnology
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LRIG1 CRISPR Activation Plasmid (h2) - sc-403210-ACT-2 from Santa Cruz Biotechnology
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LRIG1 Lentiviral Activation Particles (h) - sc-403210-LAC from Santa Cruz Biotechnology
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LRIG1 Lentiviral Activation Particles (h2) - sc-403210-LAC-2 from Santa Cruz Biotechnology
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LRIG1 siRNA (h) - sc-60966 from Santa Cruz Biotechnology
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LRIG1 shRNA Plasmid (h) - sc-60966-SH from Santa Cruz Biotechnology
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LRIG1 shRNA (h) Lentiviral Particles - sc-60966-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU143841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12680 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12680 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09512 from Sigma-Aldrich
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LRIG1 siRNA (Human) - CRH8656 from Cohesion Biosciences
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shRNA set against Human LRIG1 (NM_015541.2) - SHH333863 from Creative biogene
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shRNA set against Human LRIG1(NM_015541.2) - SHH160823 from Creative biogene
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LRIG1 shRNA Plasmid (Human) - CHH8656 from Cohesion Biosciences
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LRIG1 miRNA 3'UTR clone - MiUTR1H-05894 from Creative biogene
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