Gene Symbol | USP25 |
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Entrez Gene | 29761 |
Alt Symbol | USP21 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 25 |
Other Description | USP on chromosome 21|deubiquitinating enzyme 25|ubiquitin carboxyl-terminal hydrolase 25|ubiquitin thioesterase 25|ubiquitin thiolesterase 25|ubiquitin-specific processing protease 25 |
Swissprots | Q9H9W1 Q9UHP3 Q6DHZ9 C0LSZ0 |
Accessions | EAX10041 EAX10042 EAX10043 EAX10044 EAX10045 Q9UHP3 AF134213 AAF24998 AF170562 AAF32263 AK022447 BAB14037 AK022574 BAB14107 AK094083 BC015930 AAH15930 BC018686 BC075792 AAH75792 BI256537 BM149594 BQ215557 FJ763652 ACN76567 HG765100 CDJ98632 XM_005260949 XP_005261006 XM_006723992 XP_006724055 XM_011529529 XP_011527831 XM_011529530 XP_011527832 XM_011529531 XP_011527833 XM_011529532 XP_011527834 XM_011529533 XP_011527835 XM_011529534 XP_011527836 XM_011529535 XP_011527837 NM_001283041 NP_001269970 NM_001283042 NP_001269971 NM_013396 NP_037528 |
Function | Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16501887, ECO:0000269|PubMed:19440361}. |
Tissue Specificity | Isoform USB25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen. Isoform USB25b is found in all tissues except heart and skeletal muscle. Isoform USB25m is heart and skeletal muscle specific. {ECO:0000269|PubMed:10644437, ECO:0000269|PubMed:11597335}. |
Human-USP25-cDNA-Clone - DC04228 from Abgent, a WuXi AppTec company
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USP25 - MBS1273362 from MyBioSource
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USP25 - MBS1272035 from MyBioSource
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Human USP25 cDNA clone(NM_013396.3) - CDFH020951 from Creative Biomart
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Human USP25 cDNA clone(NM_013396.3) - CDFH020952 from Creative Biomart
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Human USP25 ORF Clone(NM_013396.3) - CDCR296529 from Creative Biomart
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Human USP25 ORF Clone(NM_013396.3) - CDCR296530 from Creative Biomart
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Human USP25 ORF Clone(NM_013396.3) - CDCR296531 from Creative Biomart
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Human USP25 ORF Clone(NM_013396.3) - CDCL180681 from Creative Biomart
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human USP25 ORF clone - CDCH098672 from Creative Biomart
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human USP25 ORF clone - CDCH098673 from Creative Biomart
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human USP25 ORF clone - CDCH098674 from Creative Biomart
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human USP25 ORF clone - CDCH098675 from Creative Biomart
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human USP25 ORF clone - CDCH098676 from Creative Biomart
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human USP25 ORF clone - CDCH098677 from Creative Biomart
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human USP25 ORF clone (NM_013396.3) - CDCH098674 from Creative biogene
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Human USP25 ORF Clone (BC015930) - CDCS413440 from Creative biogene
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Human USP25 ORF Clone (BC075792) - CDCS413441 from Creative biogene
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Human USP25 cDNA Clone(NM_013396.3) - CDFH020951 from Creative biogene
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Human USP25 cDNA Clone(NM_013396.3) - CDFH020952 from Creative biogene
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Human USP25 (NP_037528) VersaClone cDNA - RDC1641 from R&D Systems
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