| Gene Symbol |
KLHL22
|
| Entrez Gene |
84861
|
| Alt Symbol |
KELCHL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kelch-like family member 22
|
| Other Description |
kelch-like 22|kelch-like protein 22
|
| Swissprots |
B7Z2G1 A8MTV3 D3DX30 A8K3Q4 Q53GT1 Q96KC6 Q96B68
|
| Accessions |
EAX02961 EAX02962 EAX02963 EAX02964 Q53GT1 AK024369 AK027266 BAB55007 AK222850 BAD96570 AK290669 BAF83358 AK294682 BAH11847 BC015923 AAH15923 CR456352 CAG30238 CU013062 CAK54493 CU013350 CAK54792 DA381792 XM_011530469 XP_011528771 NM_032775 NP_116164 NR_033825
|
| Function |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. {ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:23455478}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:23455478}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23455478}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23455478}. Note=Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase.
|